نتایج جستجو برای: serum amyloid
تعداد نتایج: 338050 فیلتر نتایج به سال:
The amyloid deposits that cause disease in systemic amyloidosis always contain the normal plasma protein, serum amyloid P (SAP) component. SAP is the target of a novel immunotherapy approach now being developed to eliminate amyloid deposits. The treatment is enabled by, and critically depends on, the use of the drug (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxyli...
Amyloidogenic protein aggregation is a persistent biomedical problem. Despite active research in disease-related aggregation, the need for multidisciplinary approaches to the problem is evident. Recent advances in single-molecule fluorescence spectroscopy are valuable for examining heterogenic biomolecular systems. In this work, we have explored the initial stages of amyloidogenic aggregation b...
Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflammation before presenting, most commonly with renal involvement. Using dose-dep...
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents. Objectives: The current study aimed at measuring amyloid β (Aβ) serum levels in patients with relapsing-remitting MS. Mater...
Serum amyloid A protein (SAA) is a major acute-phase protein in humans and most other mammals. In addition, it is the serum precursor of the major protein constituent of reactive amyloid fibrils. Sequence analyses have identified a number of polymorphic forms of human SAA and amyloid A protein (AA), but the question of the number of genes encoding SAA in the human has not been addressed. In add...
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