INTRODUCTION Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives. In the latter, serum antibodies are commonly regarded as potential markers of disease susceptibility. The present long-term follow-up study evaluated the fate of antibody-positive first-degree relatives. PATIENTS AND METHODS 25 patient...

The presence of serum antibodies to the diol-epoxide DNA adducts of representative polycyclic aromatic hydrocarbons (PAH), chrysene, benz[a]anthracene and benzo[a]pyrene, was determined by ELISA using serum samples obtained from normal healthy individuals. Antibodies that reacted against PAH adducted-DNA, but not against PAH-adducted protein, were found in the serum of approximately 40% of the ...

The importance of locally and systemically formed antibodies of various classes for protection against experimental cholera has been studied in mice immunized with cholera toxin. Groups of mice were given various numbers of peroral or intravenous immunizations, or a combination of both. Serum antibodies and antibodies synthesized by spleen and small intestine in vitro during tissue culture were...

We verified that antibody-binding substances in serum that interfere in two-site immunoassays involving murine antibodies are heterophilic antibodies. Incubation of serum containing heterophilic antibodies and a murine monoclonal antibody to human choriogonadotropin (hCG) leads to formation of a series of soluble immune complexes. We investigated the recognition of hCG by reagent antibody in th...

Thyroid hormone antibodies (THAbs)--i.e., antibodies to thyroxin (T4) and triiodothyronine (T3)--are detected rarely in human serum, where they are searched for, possibly because of a quantitatively minimal interaction between thyroid hormones (the haptens) and serum IgGs (the antibodies). The weak binding could result from these facts: (a) there are already six physiological carrier proteins f...

BACKGROUND To establish antibody analysis from dried blood spots (DBS) on filter paper for seroepidemiologic infection and cancer association studies, we analyzed data from a population-based study in Mongolia. METHODS Using multiplex serology, we analyzed 985 paired DBS and serum samples from the same donors for antibodies to 12 different proteins from four groups of infectious agents: human...

The mean urinary excretion in a vitamin-B(12) absorption (Schilling) test in control subjects was 19.2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19.3%, antibodies in serum only 14.4%, antibodies in gastric juice only 11.1%, and antibodies in both serum and gastric juice 8.4%. It is concluded that intrinsic-...

BackgroundAnti-CD20 antibody therapy may be associated with an increased risk of infections. We therefore investigated factors for infection in patients demyelinating diseases treated anti-CD20 therapy.MethodsIn this retrospective uncontrolled study, ever antibodies at academic clinic were identified through the Danish Multiple Sclerosis Registry (DMSR). Data collected from medical charts and D...

The main aim of this study was to determine an association between serum antibodies against adenoviruses (AdVs) type 5, 31 and 36 (as positive control) and obesity in the Polish adults and the evaluation of an association between anti-AdV antibodies status and body mass index (BMI), anthropometric measures, serum lipids and C-reactive protein (CRP). The study included 200 adults, both obese and...