PATIENTS suffering from psoriasis frequently have a low serum folate (Knowles, Shuster and Wells, 1969; Shuster, Marks and Chanarin, 1967). It is usually accepted that this is due to loss of folate in the psoriatic desquamation (Hild, 1969), though it has been suggested that increased utilisation of folate is possibly a more important factor (Touraine, Revuz, Zittoun, Jarret and Tulliez, 1973)....

Twenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lymphocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were correct...

Background: Diabetes mellitus (DM) is a common metabolic disease. Anaemia accompaniment to diabetes, particularly in patients with albuminuria or reduced renal function. more frequent and severe at any level of glomerular filtration rate (GFR) diabetics compared nondiabetic patients. Methods: One hundred type 2 diabetes were included the study. Complete blood count, serum iron profile, ferritin...

BACKGROUND In elderly individuals with low serum vitamin B-12, those who have high serum folate have been reported to have greater abnormalities in the following biomarkers for vitamin B-12 deficiency: low hemoglobin and elevated total homocysteine (tHcy) and methylmalonic acid (MMA). This suggests that folate exacerbates vitamin B-12-related metabolic abnormalities. OBJECTIVE We determined w...

AIM The adequacy of 50 mcg folic acid supplementation given to low-birth-weight babies was investigated. The folate levels of the mothers and infants, and breastmilk, and the optimum dose for folic acid supplementation were also investigated. MATERIAL AND METHODS After obtaining blood from 141 low-birth-weight infants on the 1st day of life for serum and red cell folate levels, the infants we...

BACKGROUND Folate intake has been associated with reduced colorectal cancer risk; however, few studies have prospectively examined circulating folate or other related one-carbon biomarkers. METHODS We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 50- to 69-year-old Finnish men to investigate associations between serum folate...

A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum induction mouse model. In the lipopolysaccharide injection model, the fluorescence signal intensity of NIR2-folate (n = 12) and of free NIR2 (n = 5) was compared between lipopolys...

Previously reported findings on the association between folate intake or serum folate levels and esophageal cancer risk have been inconsistent. This study aims to summarize the evidence regarding these relationships using a dose-response meta-analysis approach. We performed electronic searches of the Pubmed, Medline and Cochrane Library electronic databases to identify studies examining the eff...

OBJECTIVE To test the hypothesis that the incidence of fatal coronary heart disease and cardiovascular disease in a general population is related to serum and red cell folate and vitamin B-12 concentrations. DESIGN Cohort study with follow up of 29 years. SETTING Busselton, Western Australia. PARTICIPANTS 1419 men and 1531 women aged 20 to 90 years, who were alive more than three years af...

BACKGROUND Photodegradation of certain vitamins such as riboflavins, carotinoids, tocopherol, and folate has been well-documented. Previous observations suggest that ultraviolet (UV) radiation may cause folate deficiency. This is of great importance since folate deficiency is also known to be linked with the development of neural tube defects. To investigate the influence of UVA radiation on se...