Purpose: The objective of this study was to identify and characterize new serum biomarkers in ovarian cancer patients using mass spectrometric protein profiling and specific immunological assays. Experimental Design: Serum samples from 80 cancer patients and 91 healthy women were analyzed by surface enhanced laser desorption and ionization-mass spectrometry (MS) profiling. A candidate biomarker...

BACKGROUND Human iron status is influenced by environmental and genetic factors. We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status. METHODS Reference values of serum iron status markers were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 717 healthy adults....

Abstract The results of studies physiological fluids by differential scanning calorimetry (DSC) for the purpose diagnosis and monitoring diseases are promising. Before DSC method is accepted in medical diagnostics, it worth experimenting with various environmental conditions at research stage. Among other things, important to choose an appropriate solvent dilute tested biological fluids. In thi...

haptoglobin (hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. as an important consequence, haptoglobin-hemoglobin complex (hp-hb) shows considerable antiox...

Brusellozis birçok evcil ve yabani hayvanı etkileyen uterus, meme, testis gibi genital organlara yerleşerek süt veriminde azalma, yavru atma infertiliteye neden olan, kronik seyirli zoonoz bir hastalıktır. Yangı, doku hasarı brusella enfeksiyonlarda karaciğer tarafından sentezlenen akut faz proteinler (AFP) teşhis, tedavinin izlenmesi prognozun değerlendirilmesinde kullanılmaktadır. Bu nedenle ...

Three diluents were studied, to determine which is the best for the automated immunochemical measurement of specific serum proteins. Nine serum proteins (orosomucoid, a 1-antitrypsin, a2-macroglobulin, haptoglobin, transferrin, C3, lgG, IgA, and 1gM) were measured in physiological saline (9 g NaCI/liter), tris(hydroxymethyl)aminomethane buffer (0.01 mol/liter; pH 7.4), and physiological saline ...

Haptoglobin is a putative adiposity marker because its concentration in blood is increased in obese humans. The present studies examined haptoglobin release by explants of adipose tissue in primary culture. Haptoglobin was released by explants of human visceral and subcutaneous adipose tissue at a nearly linear rate over 48 h. Explants of visceral adipose tissue released more haptoglobin than d...

a total of 1611 serum samples collected from ten ethnically distinct populations of iran (turks and kurds of rezaieh, lurs, zabolis, baluchis, turks and kurds of shirvan, zoroastrians, tehranis and kermanis) were examined for haptoglobin, transrferrin and the third component of complement systems. the gene frequencies obtained of these samples were combined with those of the previous studies of...