Using the Escherichia coli lacZ gene to identify chromosomal loci that are transcriptionally active during growth arrest of NIH 3T3 fibroblasts, we found that an mRNA expressed preferentially in serum-deprived cells specifies the previously characterized alpha-receptor (alphaR) for platelet-derived growth factor (PDGF), which mediates mitogenic responsiveness to all PDGF isoforms. Both PDGFalph...

Cancer treatment is still of the greatest challenges that health care providers and patients are facing. One of the unsolved problems in cancer treatment is cells' reaction to metabolic stress caused by harsh nutritional conditions around tumor. In order to be able to treat this disease properly, it is important to understand the true nature of the disease. In fact, the cells inside the central...

This experiment was conducted to investigate the effects of various starvation and refeeding periods on growth, feed utilization and body composition in Asian sea bass (Lates calcarifer) with an average initial weight of 30.26±1.4 g (mean±SE). The fish were exposed to three different regimes: the control group fed twice daily to apparent satiation throughout the experiment (C), th...

p53, the " cellular gatekeeper " and the " guardian of the cellular genome " , is the most commonly mutated tumor suppressor in human cancer. In response to diverse stresses (that is, DNA damage, nutrient deprivation, oncogenic activation, hypoxia, oxidative stress, hyperproliferative signals and other forms of stress), p53 can be activated and subsequently functions as a transcription factor t...