Transepidermal water loss (TEWL) through the ventral skin of the hamster ear was determined using a modified flow-through diffusion apparatus. Tritium-labeled water was allowed to permeate through the dermal/epidermal layers. Water vapor was collected in a closed system by adsorption onto solid anhydrous calcium chloride in a separately attached receiver. The desiccant was removed, dissolved in...

Subcutaneous inoculation, of PR8 allantoic fluid, or watery suspensions of the virus obtained from allantoic fluid by high-speed centrifugation or by elution after adsorption on red cells induced serum antibodies in experimental animals, which reached the highest levels within 2 weeks after inoculation and were gradually lost thereafter. The addition of killed acid-fast bacteria (Myco. tubercul...

BACKGROUND A long-acting analgesic may be particularly desirable in patients suffering from long-lasting pain. The aim of the study was to evaluate the antinociceptive effect of a novel nalbuphine preparation and to determine its duration of action. METHODS The antinociceptive effects of i.m. nalbuphine HCl in saline and nalbuphine base in sesame oil were evaluated in rats. The in vitro drug-...

A diester prodrug of nalbuphine, sebacoyl dinalbuphine (SDN), and its long-acting formulation are currently being developed to prolong the duration of nalbuphine. A comparative in vitro hydrolysis study was conducted for SDN in rat, rabbit, dog, and human blood. Both SDN and nalbuphine in blood or plasma were measured by high-performance liquid chromatography. The hydrolysis rates of SDN in blo...

In view of the recent isolation of stable oil bodies as well as a unique oleosin from lily pollen, this study examined whether other minor proteins were present in this lipid-storage organelle. Immunological cross-recognition using antibodies against three minor oil-body proteins from sesame suggested that a putative caleosin was specifically detected in the oil-body fraction of pollen extract....

Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases, the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated. Sprague-Dawley rats were fed a diet containing the oils or trans-fat, and then body weights, blood lipids, and effects on brain infarction and physical dysfunction induced by mi...

In this study, the physical and chemical properties of linseed oil sesame seed were measured compared. The results showed that nitrogen content, total protein amino acids in 3.27%, 20.39%, 92158.22 μg/g FW, respectively, 2.79%, 17.43%, 92246.59 FW seeds correspondingly. content unsaturated fatty such as linolenic acid linoleic was 290.57 μg/g, 0.55 3326.69 μg/g、0.24 oil. addition, contents palm...

Flutamide (FLT) is an antiandrogen drug for the treatment of prostate cancer. It has the drawback of poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. Hence, it is prepared as self-nanoemulsifying drug delivery systems (SNEDDS) with an aim to enhance its dissolution rate. The objectives of the study are to develop SNEDDS of FLT and to characterize ...

this study was performed in order to evaluate the effects of spraying micronutrients iron, zinc, calcium on yield and yield components of seven sesame varieties on 2007 cropping season in research farm of shahed university. the experiment was performed as split-plot based on randomized complete blocks design with three replications. the main factor included feso4, znso4, cano3 and control (wate...