Artemisinin (ART) is a sesquiterpene lactone and popular malaria drug used in many parts of the world. Artesunate (ARTS) semi-synthetic derivative ART with improved pharmacokinetic properties. However, half-life ARTS less than an hour vivo. The analysis this vitro different solvent systems using LC-MS/TOF showed solvent-driven breakdown. breakdown formed several derivatives, including dihydroar...

Triple negative breast cancer (TNBC) is a highly metastatic cancer among the breast cancer subgroups. A thorny issue for clinical therapy of TNBC is lack of an efficient targeted therapeutic strategy. We previously created a novel sesquiterpene lactone analog (named DETD-35) derived from plant deoxyelephantopin (DET) which exhibits potent effects against human TNBC MDA-MB-231 tumor growth in a ...

Helicobacter pylori is associated with various diseases of the upper gastrointestinal tract, such as gastric inflammation and duodenal and gastric ulcers. The aim of the study was to assess anti-H. pylori effects of the sesquiterpene lactone dehydrocostus lactone (DCL) from Magnolia sieboldii leaves, compared to commercial pure DCL, two previously known sesquiterpene lactones (costunolide and p...

The main objective of the present study was to assess effects sulfur (S) nutrition on plant growth, overall quality, secondary metabolites, and antibacterial radical scavenging activities hydroponically grown lettuce cultivars. Three cultivars, namely, Pazmanea RZ (green butterhead, V1), Hawking multi-leaf lettuce, V2), Barlach (red multi-leaf, V3) were subjected two S-treatments in form magnes...