Background. Some patients with severe nonallergic asthma can be difficult to treat with conventional therapy. Mycophenolat Mofetil (MMF) is an immunosuppressive drug with multiple mechanisms. There is theoretical support of specific effect of MMF on severe asthma, in "difficult to treat" patients. The aim of the present case was to explore whether MMF had an effect in one case of severe refract...

BACKGROUND There is a need to understand more about modifiable health behaviors that may be related to asthma control. Sleep is one such health behavior that has received little attention in pediatric asthma research. OBJECTIVE To examine sleep duration, sleep hygiene, and insomnia in adolescents with and without asthma. METHODS Adolescents (n = 298; 51% boys; age range, 12-17 years; 48% wi...

Corticosteroid insensitivity (CI) is a major barrier to treating severe asthma. Despite intensive research, the molecular mechanism of CI remains uncertain. The aim of this study was to determine abnormality in corticosteroid action in severe asthma and to identify the molecular mechanism of the long-acting β(2)-adrenergic agonists (LABAs) formoterol and salmeterol on restoration of corticoster...

2 3 9 4 jci.org Volume 126 Number 7 July 2016 A brief overview Asthma identifies a spectrum of respiratory-related symptoms, typically with a link to reversible airflow limitation. Like the terms arthritis or anemia, the term asthma does not identify any specific underlying pathobiology, but is a broad, umbrella-like term that covers multiple groupings of patient characteristics or phenotypes (...

Asthma is a serious and prevalent public health problem that spans the entire world. It is estimated that asthma affects over 300 million people worldwide.1 Its prevalence is approximately 21 million citizens in the United States, according to the Centers for Disease Control and Prevention.2 Other reports indicate that as many as 9.5 million children currently have asthma in the United States.3...

OBJECTIVES We hypothesised that severe asthmatics taking a statin drug, in addition to inhaled corticosteroids/long-acting β-agonist inhaler therapy, would have better asthma symptom control and improved lung function compared to their controls. STUDY DESIGN A retrospective, cross-sectional study of 165 patients with severe asthma seen from 2001-2008. Hierarchical linear and logistic regressi...

BACKGROUND The lower airways harbor a community of bacterial species which is altered in asthma. OBJECTIVES We examined whether the lower airway microbiota were related to measures of asthma severity. METHODS We prospectively recruited 26 severe asthma, 18 non-severe asthma and 12 healthy subjects. DNA was extracted from induced sputum and PCR amplification of the V3-V5 region of bacterial ...

Asthma is an inflammatory and chronic disease that affects about 300 million people globally. The disease is more common in developed countries. The increase in the prevalence of asthma is not only due to genetic factors, but also to many environmental factors related to urbanization and type of nutrition. It has been reported that obesity is an independent risk factor for asthma and obese chil...

Effective treatment of severe asthma is a major unmet need because patients' symptoms are not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly controlled because of poor adherence to controller therapy, and this might be addressed by using combination inhalers that contain a corticosteroid and long-acting β(2)-agonist as reliever therapy in addition to mainten...