BACKGROUND/AIM The most important ethiology factor of chronic liver disease that progresses into terminal insufficiency is hepatitis C virus (HCV) infection. Intravenous (iv) drug abuse is the main cause for spreading HCV. Thus the therapy for such patients is of extreme importance in reducing the incidence of the disease. The aim of the study was to establish efficacy of a combined therapy wit...

Background: Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions the regulation of immunity are mediated by receptors (VDRs). Polymorphisms VDR gene have associated with several health outcomes; however, their effects on still need more clarification. This study aims to investigat...

conclusions hiv/hcv co-infection is an important medical problem in north-eastern poland. a history of incarceration and younger age at hiv diagnosis were additional to idu risk factors for hcv seropositivity in this cohort. patients and methods adult hiv-1 infected patients, with at least one antihcv result, treated in one of polish hiv/aids reference centers, participated in this cross-sectio...

The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implic...

Background and aimsPseudoxanthoma elasticum (PXE) is caused by variants in the ABCC6 gene. It results calcification skin, peripheral arteries eyes, but has considerable phenotypic variability. We investigated association between genotype clinical phenotypes these different organs.MethodsABCC6 sequencing was performed 289 PXE patients. Genotypes were grouped as two truncating, mixed, or non-trun...

OBJECTIVE To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. DATA SOURCES Forty research teams contributed data on APOE genotype, sex, age at disease onset, and ethnic background for 5930 patients who met criteria for probable or definite AD and 8607 controls with...

A genetical model is formulated in which the sex ratio in broods and the relative size of broods are determined by the genotype at an autosomal locus. The results also apply to the case in which the sex-ratio locus is sex linked and expressed in the homogametic sex and to the case in which the locus is expressed in the diploid sex of a haplodiploid organism. Fisher (1930) argued that the sex ra...