Carboxylesterase (CES) 1 and CES2 are two major hepatic hydrolases responsible for the metabolism of numerous endogenous and exogenous compounds. In this study, age- and sex-dependent expression and activity of CES1 and CES2 were investigated using both animal models and individual human liver s9 samples. The expression and activity of mouse CES1 (mCES1) and mCES2 in the liver were markedly low...

the present study aimed to evaluate the effects of ramadan fasting on the level of sex hormones in girls between 9-13 years before age at menarche.this study was conducted on a sample of 58 subjects (age range: 9-13 years), who were divided intotwo groups of fasting (n=31) and non-fasting (n=27). the levels of follicle-stimulating hormone(fsh), luteinizing hormone (lh), progesterone and estradi...

Abstract Objective To evaluate the genetic effects of sex hormone traits on development mental in middle-aged adults. Methods The SNPs associated with were derived from a two-stage genome-wide association study (GWAS). Four selected current study, including hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. polygenic risk score (PRS) calculated individual-le...

RATIONALE Lipoid congenital adrenal hyperplasia (LCAH) is extremely rare, but is the most fatal form of congenital adrenal hyperplasia resulting from mutations in the steroidogenic acute regulatory protein (STAR) gene. LCAH arises from severe defects in the conversion of cholesterol to pregnenolone, the precursor of all steroids. PATIENT CONCERNS A case was reported that an 11-month-old Chine...

BACKGROUND Opioids can exert adverse effects on the body. Morphine, an opioid drug, reduces hormone levels and fertility, and causes sexual activity disorders. Tribulus terrestris (TT) is a traditional herbal medicine used to enhance sexual activities. This study investigates the possible role of TT on sex hormones and gonadotropins with the intent to show its usefulness in treating fertility d...

Opposite-sex attraction in most mammals depends on the fine-tuned integration of pheromonal stimuli with gonadal hormones in the brain circuits underlying sexual behaviour. Neural activity in these circuits is regulated by sensory processing in the accessory olfactory bulb (AOB), the first central station of the vomeronasal system. Recent evidence indicates adult neurogenesis in the AOB is invo...