PurposeTo evaluate the effect of select baseline characteristics on geographic atrophy (GA) progression in eyes receiving intravitreal pegcetacoplan or sham.DesignPhase 2 multicenter, randomized, single-masked, sham-controlled trial.MethodsPatients with GA received 15 mg monthly every other month (EOM), sham injection EOM for 12 months. Primary efficacy endpoint was change lesion size (square r...

The role of ovarian hormones, nitric oxide, and their interaction on learning and memory has been widely investigated. The objective of present study was to investigate different effects of chronic administration of inducible nitric oxide synthase inhibitor, aminoguanidine (AM) on learning and memory of ovariectomized (OVX) and naïve (Sham) female rats. Thirty-two rats were divided into four gr...

PURPOSE We sought to compare the effects of external pneumatic compression (EPC) and sham when used concurrently with resistance training on performance-related outcomes and molecular measures related to recovery. METHODS Twenty (N = 20) resistance-trained male participants (aged 21.6±2.4 years) were randomized to balanced sham or EPC intervention groups. The protocol consisted of 3 consecuti...

The aim of this study was to test and compare the effects of a within-subject design of repetitive transcranial magnetic stimulation (rTMS) [coupled with sham transcranial direct current stimulation (tDCS)] and tDCS (coupled with sham rTMS) on the motor cortex excitability and also compare the results against sham tDCS/sham rTMS. We conducted a double-blinded, randomized, sham-controlled, cross...

Phytochrome-mediated germination of Lactuca sativa L. cv. Waldmann's Green seeds was inhibited strongly by 10 millimolar salicylhydroxamic acid (SHAM), but only slightly delayed by the same level of KCN. SHAM was most effective if applied within the 8-hour potentiation period (release from dormancy) following red light treatment, but much less effective with completely potentiated seeds. SHAM a...

Abstract Introduction The Urogold 100 MTS™ electrohydraulic shockwave device is FDA cleared for improved blood flow and connective tissue activation; retrospective studies in ED patients have shown positive outcome. Objective To perform an interim analysis of sham active treatment changes primary outcome measures grayscale ultrasound DUS. Methods A single-blind, sham-controlled, randomized, pro...

Objective- This study was designed to determine the effect of pomegranate seed oil (PSO) treatment on oxidative stress and lipid profiles in ovariectomized (OVX) rats. Design- Experimental study Animals- 24 female Wistar rats Procedures-The rats were randomly divided into four groups: sham-operated (SHAM), SHAM with PSO treatment (SHAM + PSO), ovariectomized (OVX), and ovariectomized with PSO t...

The purpose of this study was to determine whether sinoaortic deafferentation (SAD) alters the severity of hypertension or sympathoadrenal contribution to mean blood pressure (MAP) during renal wrap hypertension. Male Sprague-Dawley rats were implanted with radiotelemetry transmitters for 24-hour recording of MAP and heart rate. All rats underwent either SAD or sham SAD (Intact) surgery and wer...

Exercise training (ExT) normalizes the increased sympathetic outflow in heart failure (HF), but the underlying mechanisms are not known. We hypothesized ExT would normalize the augmented activation of the paraventricular nucleus (PVN) via an angiotensinergic mechanism during HF. Four groups of rats used were the following: 1) sham-sedentary (Sed); 2) sham-ExT; 3) HF-Sed, and 4) HF-ExT. HF was i...

The effects of truncal vagotomy and parietal cell vagotomy on gastric acid secretion and plasma gastrin and pancreatic polypeptide release were studied in 28 duodenal ulcer patients under basal conditions and after modified sham feeding and infusion of pentagastrin (2 micrograms/kg/h). Before vagotomy gastric acid output in response to modified sham feeding was significantly higher than basal a...