Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress-induced transendothelial neutro...

In composite plate structures, it is common to combine di erent materials with very di erent Young's moduli and densities. Damping treatments can also be added to prevent high levels of vibration. For discretized problems, the static and dynamic behavior of such heterogeneous structures can be carried out with the 3D elasticity theory but this often leads to very large systems. Therefore, plate...

in this paper, dissimilar resistance spot welding of aisi 1075 eutectoid steel to aisi 201 stainless steel is investigated experimentally. for this purpose, the experiments are designed using response surface methodology and based on four-factor, five-level central composite design. the effects of process parameters such as welding current, welding time, cooling time and electrode force are inv...

The investigation aims at: (i) constructing a modified higher-order shear deformation theory in which Kirchhoff's hypotheses are relaxed, to allow for shear deformations; (ii) validating the present 5-parameter-smeared-laminate theory by comparing the results with exact solutions; and (iii) applying the theory to a specific problem of the postbuckling behavior of a flat stiffened fiber-reinforc...

The primary response transcription factor, early growth response-1 (Egr-1), is rapidly activated by a variety of extracellular stimuli. Egr-1 binds to a sequence found in the promoters of genes involved in vascular injury, such as PDGF-A and tissue factor, and trans-activates their expression in endothelial cells in response to fluid shear stress. Here we show that egr-1 mRNA is increased after...

Weak lensing by large-scale structure is an invaluable cosmological tool given that most of the energy density of the concordance cosmology is invisible. Several large groundbased imaging surveys will attempt to measure this effect over the coming decade, but reliable control of the spurious lensing signal introduced by atmospheric turbulence and telescope optics remains a challenging problem. ...

BACKGROUND AND PURPOSE Aortic stenosis, causing flow abnormalities, disturbs the normal hemodynamics in the common carotid arteries. The aim of the present study was to investigate the remodeling process of the common carotid arteries after surgical correction of aortic stenosis. METHODS Eleven subjects with aortic stenosis were studied before and 1 and 6 months after aortic valve replacement...

We have modeled platelet aggregation in a linear shear flow by accounting for two body collision hydrodynamics, platelet activation and receptor biology. Considering platelets and their aggregates as unequal-sized spheres with DLVO interactions (psi(platelet) = -15 mV, Hamaker constant = 10(-19) J), detailed hydrodynamics provided the flow field around the colliding platelets. Trajectory calcul...

A comprehensive experimental study that quantifies the influence of coupled compression and shear wave loading on liquefaction susceptibility sands is presented. Such typical in situ, leads to complex principal stress rotation, which turn impacts potential for soils even if cyclic intensity remains constant. The nature degree rotation caused by this are significantly influenced initial consolid...

BACKGROUND AND PURPOSE Vascular abnormalities, such as atherosclerosis and the growth and rupture of cerebral aneurysms, result from a derangement in tissue metabolism and injury that are, in part, regulated by hemodynamic stress. The purpose of this study was to establish the feasibility and accuracy of determining wall shear rate in the internal carotid artery from phase-contrast MR data. M...