We have previously demonstrated that the NKR repertoire is profoundly disrupted by SHIP deficiency. This repertoire disruption is characterized by receptor dominance where inhibitory signals from 2B4 repress killing of complex targets expressing MHC class I and activating ligands. In this study, we examine the molecular basis of receptor dominance in SHIP-/- NK cells. In this study, we show tha...

Abstract Work in the engine department is currently demanding more monitoring task. However, current alarm systems that support operators during troubleshooting are deficient. In many cases, reach control room (ECR) only to find a false alarm. This problem likely aggravate future as work smaller numbers or even alone; therefore, task prioritization should be considered given context. Therefore,...

The termination of activation signals is a critical step in the control of the immune response; perturbation of inhibitory feedback pathways results in profound immune defects culminating in autoimmunity and overwhelming inflammation. FcgammaRIIB receptor is a well described inhibitory receptor. The ligation of B-cell receptor (BCR) and FcgammaRIIB leads to the inhibition of B-cell activation. ...

We report about a hierarchical design for extracting ship features and recognizing ships from SAR images, and which will eventually feed a multisensor data fusion system for airborne surveillance. The target is segmented from the image background using directional thresholding and region merging processes. Ship end-points are then identified through a ship centerline detection performed with a ...

In recent years a great deal of research efforts in ship hydromechanics have been devoted to practical navigation problems in moving larger ships safely into existing harbours and inland waterways and to ease congestion in existing shipping routes. The starting point of any navigational or design analysis lies in the accurate determination of the hydrodynamic forces generated on the ship hull m...

The inositol phosphatases phosphatase and tensin homologue (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP) negatively regulate phosphatidylinositol-3-kinase (PI3K)-mediated growth, survival, and proliferation of hematopoietic cells. Although deletion of PTEN in mouse T cells results in lethal T cell lymphomas, we find that animals lacking PTEN or SHIP in B cells show no ...

With the rapid development of spaceborne synthetic aperture radar (SAR) and the increasing need of ship detection, research on adaptive ship detection in spaceborne SAR imagery is of great importance. Focusing on practical problems of ship detection, this paper presents a highly adaptive ship detection scheme for spaceborne SAR imagery. It is able to process a wide range of sensors, imaging mod...