نتایج جستجو برای: shotgun assembly sequences
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MOTIVATION The de novo assembly of genomes from whole- genome shotgun sequence data is a computationally intensive, multi-stage task and it is not known a priori which methods and parameter settings will produce optimal results. In current de novo assembly projects, a popular strategy involves trying many approaches, using different tools and settings, and then comparing and contrasting the res...
The ongoing success of the proteomics endeavor is the result of a prolific symbiosis between experimental ingenuity [2, 3, 4] and efficient bioinformatics [5, 6, 7, 8, 9, 10, 11]. Without these, ground-breaking landmarks such as the human genome project [12, 13] or the HUPO initiative [14] would likely not have seen the light of day. But despite valuable contributions, the road to a better unde...
Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates
As more research centers embark on sequencing new genomes, the problem of DNA fragment assembly for shotgun sequencing is growing in importance and complexity. Accurate and fast assembly is a crucial part of any sequencing project and many algorithms have been developed to tackle it. Since the DNA fragment assembly problem is NP-hard, exact solutions are very difficult to obtain. Various heuris...
The emergence of next-generation sequencing platforms led to resurgence of research in whole-genome shotgun assembly algorithms and software. DNA sequencing data from the Roche 454, Illumina/Solexa, and ABI SOLiD platforms typically present shorter read lengths, higher coverage, and different error profiles compared with Sanger sequencing data. Since 2005, several assembly software packages hav...
Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease. The initial reference genome sequence reported more than a decade ago had a profound impact on progress in Drosophila research, and improving the accuracy and completeness of this sequence continues to be important to further progress. We ...
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