نتایج جستجو برای: sideroblastic anemia
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ABSTRACT : RELATIONSHIP OF SYSTEMIC LUPUS ERYTHEMATOSUS ACTIVITIES BASED ON MEX-SLEDAI SCORE WITH INCIDENCE ANEMIA IN ERYTHEMATOUS PATIENTS THE ODAPUS LAMPUNG COMMUNITY, 2020Background Systemic Lupus Erytematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against cell nucleus and involving many organ systems in body. Anemia LES patients varies between ...
Introduction THE simultaneous occurrence in the bone marrow of megaloblasts and ring-sideroblasts may result from a variety of causes. In a series of seventy patients with sideroblastic anaemia, MacGibbon and Mollin (1965) observed megaloblastic change in 544O of cases of primary sideroblastic anaemia, and in 74YO of cases of secondary sideroblastic anaemia. The megaloblastic change was attribu...
Acquired sideroblastic anemia with unilineage dysplasia (WHO RARS) is a clonal stem cell disorder characterized by erythroid dysplasia, mitochondrial accumulation of mitochondrial ferritin, defective erythroid maturation and anemia. A fraction of these patients also show elevated platelet counts; since 2001 this has been defined as RARS with marked thrombocytosis (RARS-T). It has recently been ...
SOD2 is an antioxidant protein that protects cells against mitochondrial superoxide. Hematopoietic stem cells (HSCs) lacking SOD2 are capable of rescuing lethally irradiated hosts, but reconstituted animals display a persistent hemolytic anemia characterized by increased oxidative damage to red cells, with morphologic similarity to human "sideroblastic" anemia. We report further characterizatio...
Retinitis pigmentosa (RP) is a highly heterogeneous group of disorders characterized by degeneration of the retinal photoreceptor cells and progressive loss of vision. While hundreds of mutations in more than 100 genes have been reported to cause RP, discovering the causative mutations in many patients remains a significant challenge. Exome sequencing in an individual affected with non-syndromi...
The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent in non-Hispanic white women, and nearly 20 percent in black and Mexican-American women. Nine percent of patients older than 65 years with iron deficiency anemia have a gastrointestinal cancer when evaluated. The U.S. Preventive Services Task Force currently recommends screening for iron deficiency anemia in preg...
A 15-month-old male infant was admitted because of anemia lasting for a few months and delayed weight gain. There was no family history of anemia. At admission, the patient was pale but showed no other pathological findings. Hematological data were: Hb 8.6 g/dL, red cell count 4.8631012/L, Hct 28%, MCV 57.6 fL, MCH 17.7 pg, MCHC 30.7 g/dL, reticulocytes 1943109/L, white cell count 18.93109/L wi...
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