Abstract Primary central nervous system (CNS) tumors are now the most common cause of childhood cancer–related deaths. Pediatric high-grade gliomas (pHGGs) among lethal brain with a 5-year survival rate only 20%. MYCN pHGGs represent one subgroup an unmet need for therapeutics. belongs to family MYC transcription factors that regulate numerous cancer hallmarks such as proliferation, apoptosis, ...