Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and homeostasis by elaborate modulatory mechanisms. MicroRNAs (miRNAs) have emerged...

Filaggrin (FLG) is a key cornified envelope and epidermal barrier protein. FLG mutations are the most strongly implicated genetic risk factor for atopic eczema (AE). part of gene complex, called differentiation complex (EDC), genes which contribute to various aspects function. siRNA knockdown in keratinocytes caused global reduction EDC Keratin (KRT) expression concomitant with up-regulation bo...

EDITORIAL article Front. Mol. Neurosci., 22 August 2023Sec. Molecular Signalling and Pathways Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1271369