Adaptation to hypoxia depends on a conserved α/β heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose α-subunit is regulated by oxygen through different concurrent mechanisms. In this study, we have identified the RNA binding protein dMusashi, as a negative regulator of the fly HIF homologue Sima. Genetic interaction assays suggested that dMusashi participates of the ...

How a human being learns is a wide field and not fully understood until now. This paper should give an alternative attempt to get closer to the answer how human beings learn something and what the relation to emotions is. Therefore, the cognitive architecture of the project “Simulation of Mental Apparatus and Applications (SiMA)” is used to fulfill two tasks. One is to give an answer to the que...

In this study we examine the labial and occlusal surfaces of incisors and canines of hominins recovered from the Sima de los Huesos (SH), middle Pleistocene site, in order to establish the possible extra-masticatory use of anterior teeth. We have compared the microwear of these fossils with microwear from the anterior teeth of Australian Aborigines, a population characterized by ethnographic ev...

Abstract. This paper focuses on total least squares (TLS) problems AX ≈ B with multiple right-hand sides. Existence and uniqueness of a TLS solution for such problems was analyzed in the paper [I. Hnětynková, M. Plešinger, D. M. Sima, Z. Strakoš, and S. Van Huffel (2011)]. For TLS problems with single right-hand sides the paper [C. C. Paige and Z. Strakoš (2006)] showed how a necessary and suff...

Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human neuroblastoma cells to protease activity derived from botulinum neurotoxin type C. We show that following retinoic acid treatment, human neuro...