single chain antibody

farideh hosseinzadeh shiraz hiv/aids research center, shiraz university of medical sciences, shiraz, iran-recombinant antibody laboratory, department of immunology, shiraz university of medical sciences, shiraz, iran s. saeed mohammadi shiraz hiv/aids research center, shiraz university of medical sciences, shiraz, iran-recombinant antibody laboratory, department of immunology, shiraz university of medical sciences, shiraz, iran foroogh nejatollahi tel: +98 71 32351575; fax: +98 71 32351575

background: cytotoxic t lymphocyte–associated antigen 4 (ctla-4) molecules are expressed on t-cells and inhibit their function by inhibiting activation of subsequent t-cell molecular pathways. blocking of ctla-4 inhibits the growth of malignant tumor cells. anti-ctla-4 monoclonal antibodies activate the immune system against cancer. due to several advantages of single-chain antibodies (scfvs) ...

متن کامل

Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

Journal: :Cold Spring Harbor protocols 2011

Jennifer Andris-Widhopf Peter Steinberger Roberta Fuller Christoph Rader Carlos F Barbas

The development of therapeutic antibodies for use in the treatment of human diseases has long been a goal for many researchers in the antibody field. One way to obtain these antibodies is through phage-display libraries constructed from human lymphocytes. This protocol describes the construction of human scFv (single chain antibody fragment) libraries using a short linker (GGSSRSS) or a long li...

متن کامل

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید