Molecular Imaging Techniques Molecular imaging of the brain aims to quantify various biological processes via the modeling of interactions between a molecular probe and a molecule of interest naturally occurring in a living organism. Brain molecular-imaging techniques such as positron emission tomography (PET) and single photon emission tomography (SPECT) allow clinical investigators to record ...

Bone scintigraphy is a sensitive and popular method for imaging a wide array of benign or malignant skeletal abnormalities. However, the uptake of tracers used for bone scintigraphy may be observed in various extraosseous sites, thereby limiting its specificity. It is difficult to correctly localize such sites of uptake on planar bone scintigraphy alone. The addition of hybrid single-photon emi...

A 47-year-old man presented with carotid rete mirabile manifesting as subarachnoid hemorrhage (SAH). Computed tomography showed SAH, and angiography disclosed an abnormal vascular network around the petrous and cavernous portions of the internal carotid artery. Single photon emission computed tomography (SPECT) with technetium-99m methyl cysteinate dimer revealed reduced regional cerebral blood...

The cause of low back pain due to lumbosacral transitional vertebra (LSTV) still remains a debated topic. Functional imaging with bone scintigraphy has been a valuable adjunct in its assessment; however, in recent years, the additional utility of single-photon emission tomography with computed tomography (SPECT/CT) is evolving as the imaging modality of choice in identifying range of complex lo...

Cerebral and cerebellar symptoms are frequently associated with Legionnaires' disease. However, corresponding brain lesions are difficult to demonstrate using either computed tomography (CT) or magnetic resonance imaging (MRI). We report here two patients with Legionella pneumophila pneumonia accompanied by prolonged neurologic symptoms. In contrast to brain CT and MRI, which failed to detect a...

We studied the radioisotope iodine-123-iodoamphetamine ([123I]IMP) and its performance in single-photon emission computed tomographic (SPECT) studies of cerebral blood flow (CBF). In seven normal volunteers, IMP/SPECT CBF measurements were calculated using a two-compartment model and were compared with the results of CBF measurements utilizing (O15)-H2O and positron emission tomography (PET). C...

This paper intends to compare the abilities of the two major imaging modalities in nuclear medicine imaging: Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT). The motivations are many-fold: (i) To gain a better understanding of the strengths and limitations of the two imaging modalities in the context of recent and ongoing developments in hardware and so...

A SPECT (single photon emission computed tomography using Tc-99m HMPAO) study of brain with segmental quantitative analysis was conducted to access the cerebral perfusion in cases of Downs syndrome (DS). Varying level of brain hypo-perfusion was documented, probably explaining the neurophysiologic basis of cognitive and neuropsychological deficits, which are not well understood in DS.

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

The mathematical derivation for the inversion of the exponential Radon transform is presented and the implementation of the inversion is detailed. The inversion can be verified and implemented by the readers for practical applications, such as for quantitative reconstruction of brain SPECT (single-photon emission computed tomography).