Orbital apex syndrome is commonly been thought to have a poor prognosis. Many cases of this syndrome have been reported to be caused by paranasal sinus mycosis. We encountered a very rare case (60-year-old woman) of sinusitis with orbital apex syndrome due to Pseudomonas aeruginosa infection. She had received insulin and dialysis for diabtes and diabetic nephropathy, moreover anticoagulants aft...

INTRODUCTION SICK SINUS SYNDROME The sinus node is composed of a collection of specialised pacemaker cells embedded in a fibrous matrix that lies in the sulcus terminalis between the superior vena cava and the right atrial appendage. The sinus node serves as the primary cardiac pacemaker and controls the heart rate in normal individuals. Recent research indicates, that the sinus node is a heter...

We report here on a case of congenital Klippel-Trenaunay syndrome with vascular abnormalities in the central nervous system. A 15-year-old male patient was hospitalized for headache. The neurological examination revealed that the patient was physiognomically sluggish and unresponsive. A general examination found that the right upper arm and the left lower leg of the patient displayed hemihyperp...

BACKGROUND Recent genome-wide association studies have demonstrated an association between MYH6, the gene encoding α-myosin heavy chain (α-MHC), and sinus node function in the general population. Moreover, a rare MYH6 variant, R721W, predisposing susceptibility to sick sinus syndrome has been identified. However, the existence of disease-causing MYH6 mutations for familial sick sinus syndrome a...

Seventy patients have been paced for carotid sinus syndrome over four years. Twelve patients had persistent symptoms despite adequate ventricular pacing. Patients with persistent symptoms were found to have a significant vasodepressor response, a significant hypotensive response to ventricular pacing (pacemaker effect), and a severe hypotensive response to carotid sinus massage with introductio...

AIM to determine the positive yield of carotid sinus massage in different patient groups: unexplained syncope, falls, dizziness and controls. DESIGN observational study. SETTING teaching hospital. METHODS we studied consecutive patients over the age of 60 years referred to the 'falls clinic' with a history of unexplained syncope, unexplained falls and unexplained dizziness. We also studie...

OBJECTIVE To investigate ventricular sympathetic innervation in patients with sick sinus syndrome and to detect regional deterioration of adrenergic innervation caused by asynchronous ventricular activation from right ventricular pacing. DESIGN Prospective controlled study. SETTING Tertiary cardiac referral centre. PATIENTS 22 patients with sick sinus syndrome and indications for permanen...

Patients with sick sinus syndrome have abnormalities of the sinoatrial node. We have measured the heart rate response to exercise in 7 patients with sick sinus syndrome without significant associated heart disease (group A) mean age 53.4 years, and compared this with 7 'normal' patients who were age-matched to within 5 years (group B), and 7 younger, well-trained subjects (group C). All underwe...