Neural tube defects (NTDs) are very frequent congenital abnormalities in humans. Recently, we have documented independent association of Vangl1 and Vangl2 gene mutations with NTDs. In the Looptail mouse, homozygosity (but not heterozygosity) for loss-of-function alleles at Vangl2 causes the severe NTD craniorachischisis, whereas heterozygosity for mutant variants of VANGL1 is associated with NT...

a dissolved methane sensor based on silicone tube was designed, constructed and optimized.the silicone tube diameter, silicone tube length and helium flow rate (as the carrier gas(were considered as process parameters to be optimized.a continuous stream of helium (50 ml/min) was directed through the tubing, sweeping out the dissolved methane which diffused through the walls of the tubing from t...

Sinusoidal obstruction syndrome is a life-threatening complication that can occur after haematopoietic stem cell transplantation. Defibrotide (DF) has been approved for the treatment of individuals with severe sinusoidal obstruction syndrome following haematopoietic stem cell transplantation in the European Union and the United States. However, the precise mechanisms by which DF protects endoth...

this paper investigates axial compression process of multi-layered tubes with circular cross-section under the axial loading in the quasi-static condition using experimental method. some specimens are prepared in seven different groups, namely; empty carbon/epoxy composite tubes, solid carbon/epoxy composite rods, empty copper tubes, composite tubes with silicon sealant filler, concentrically s...

A dissolved methane sensor based on silicone tube was designed, constructed and optimized.The silicone tube diameter, silicone tube length and helium flow rate (as the carrier gas(were considered as process parameters to be optimized.A continuous stream of helium (50 mL/min) was directed through the tubing, sweeping out the...

In the present study, an experimental study is carried out to investigate the effect of adding Al and Cu nanoparticles to the base fluid (water) on the heat transfer rate in a spirally coiled tube. The spirally coiled tube is fabricated from the straight copper tube with the inner and outer coil diameters of 100 and 420 mm, respectively. The experiments have been done for water and two types of...

Measuring thresholds for the detection of brief decrements in the level of a sinusoid is an established method of estimating auditory temporal resolution. Generally, a background noise is added to the stimulus to avoid the detection of the "spectral splatter" introduced by the decrement. Results are often described in terms of a temporal-window model, comprising a band-pass filter, a compressiv...

Three-dimensional free bending is a new tube forming technology with continuous variable curvature. In order to improve the quality of tube, this paper studies principle three-dimensional system and numerical calculation moment in detail, it uses finite element simulation model mechanism process. The used simulate process copper influence key parameters on analyzed,the shape inner cavity die ga...