نتایج جستجو برای: sirtuins
تعداد نتایج: 972 فیلتر نتایج به سال:
Why and how we age remains a topic that has kept molecular biologists busy for the past few decades. In recent years, several studies pointed to sirtuins as important players in lifespan regulation, yet, in vivo proof for most of the mammalian homologs was missing. In this issue of The EMBO Journal, Sinclair and colleagues provide novel evidence that SIRT2 is indeed a critical modulator of agin...
The sirtuins are NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that play roles in metabolic homeostasis, stress response and potentially aging. This enzyme family resides in different subcellular compartments, and acts on a number of different targets in the nucleus, cytoplasm and in the mitochondria. Despite their recognized ability to regulate metabolic processes, the r...
The Saccharomyces cerevisiae genome encodes five sirtuins (Sir2 and Hst1-4), which constitute a conserved family of NAD-dependent histone deacetylases. Cells lacking any individual sirtuin display mild growth and gene silencing defects. However, hst3Δ hst4Δ double mutants are exquisitely sensitive to genotoxins, and hst3Δ hst4Δ sir2Δmutants are inviable. Our published data also indicate that ph...
NAD(+) plays crucial roles in a variety of biological processes including energy metabolism, aging, and calcium homeostasis. Multiple studies have also shown that NAD(+) administration can profoundly decrease oxidative cell death and ischemic brain injury. A number of recent studies have further indicated that NAD(+) administration can decrease ischemic brain damage, traumatic brain damage and ...
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