Escitalopram is a commonly prescribed antidepressant of the selective serotonin reuptake inhibitor class. Clinical evidence and mapping of the serotonin transporter (SERT) identified that escitalopram, in addition to its binding to a primary uptake-blocking site, is capable of binding to the SERT via an allosteric site that is hypothesized to alter escitalopram's kinetics at the SERT. The studi...

since bone marrow has been shown to contain osteoprogenitor cells, an experiment was devised to test its effects when injected percutaneously into osteotomies sites in rabbit radii. in this experimental study, the osteogenicity and its effect on early bone repair of bone marrow grafts were investigated. the purpose of this study was to determine whether bone marrow grafted percutaneously led to...

background: research project risks are uncertain contingent events or situations that, if transpire, will have positive or negative effects on objectives of a project. the management of health and safety at work (mhsw) regulations 1999 require all employers and the self-employed persons to assess the risks from their work on anyone who may be affected by their activities. risk assessment is the...

background & aims of the study: leachate production is a major problem for solid waste landfills and causes important threat to health public and environment. one of the typical properties of heavy metals is that they cannot easily decompose in the environment. the aim of this study was to measure of heavy metals concentrations in old-age leachate from qazvin landfill site, iran. materials & me...

background surgical site infections (ssis) are the most common nosocomial infections in surgical patients. depending on the source of a traumatic wound, particular pathogens are expected to be present while their prevalence varies in different conditions. this study focused on determination of microorganisms in traumatic wound infection and the frequency of staphylococcus aureus and other organ...

background: mosquitoes lay eggs in a wide range of habitats with different physicochemical parameters. ecological data, including physicochemical factors of oviposition sites, play an important role in integrated vector management. those data help the managers to make the best decision in controlling the aquatic stages of vectors especially using source reduction. methods: to study some physico...

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A single site in the middle of the coding sequence of the hisG gene of Salmonella is required for most of the polar effect of mutations in this gene. Nonsense and insertion mutations mapping upstream of this point in the hisG gene all have strong polar effects on expression of downstream genes in the operon; mutations mapping promotor distal to this site have little or no polar effect. Two prev...