Fish oil (mainly omega 3 polyunsaturated fatty acids), differently from lard (mainly saturated fatty acids) has been suggested to have anti-inflammatory effects associated with amelioration of insulin sensibility. An important role in skeletal muscle insulin resistance development has been recently attributed to mitochondrial dynamic behavior. Mitochondria are dynamic organelles that frequently...

valproic acid is one of the main antiepileptic drugs. there is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid. there is a hypothesis that one biochemical abnormality underlying the teratogenicity of valproic acid is a drug-induced reduction in maternal plasma zinc .in the present experimental study mated rats ...

background if skeletal system does not have a correct form in childhood, certainly person will face many problems in the later stages of life. this study aimed to evaluate the prevalence of skeletal disorders in primary school students in abadan, 2015. materials and methods  this cross-sectional study was conducted on 383 primary school students in abadan, iran, which were selected by cluster s...

Myosin binding protein-C (MyBP-C) exists in three major isoforms: slow skeletal, fast skeletal, and cardiac. While cardiac MyBP-C (cMyBP-C) expression is restricted to the heart in the adult, it is transiently expressed in neonatal stages of some skeletal muscles. However, it is unclear whether this expression is necessary for the proper development and function of skeletal muscle. Our aim was ...

Skeletal dysplasias are a group of rare genetic disorders that affect growth and development the skeleton, leading to physical deformities other medical problems. High-throughput genome sequencing technologies have made it easier genotype disorder, but do not always reflect phenotypic outcome. CHST3-related skeletal dysplasia is caused by reduced function carbohydrate sulfotransferase sulfates ...

In order to identify novel genes expressed in skeletal muscle we performed a subtractive hybridization for genes expressed in human skeletal muscle but not in other tissues. We identified a novel scalloped interaction domain (SID) containing protein in humans and in the mouse, which we named VITO-1. Highest homology of VITO-1 was found with the Drosophila vestigial and the human TONDU proteins ...

The pubertal growth spurt and dental, skeletal, and pubertal development have been investigated in a prospective longitudinal study of 212 randomly selected Swedish children by means of maturation level indicators suitable for use in clinical orthodontics. The sample was examined from birth to adulthood and included a representative proportion of early-, average-, and late-maturing subjects. Th...

The goal of this study was to identify novel factors that mediate skeletal muscle development or function. We began the study by searching the gene expression databases for genes that have no known functions but are preferentially expressed in skeletal muscle. This search led to the identification of the Src homology three (SH3) domain and cysteine rich (C1) domain 3 (Stac3) gene. We experiment...

Wei Y, Chen K, Whaley-Connell AT, Stump CS, Ibdah JA, Sowers JR. Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species. Am J Physiol Regul Integr Comp Physiol 294: R673–R680, 2008. First published December 19, 2007; doi:10.1152/ajpregu.00561.2007.—The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease (CVD), nonalcoholic f...

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease. It also causes skeletal muscle dysfunction, which is responsible for reduced exercise capacity commonly seen in heart failure. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac and skeletal muscle dysfunction in heart failure ...