Skin cancer incidence is highest in white-skinned people. Within this group, skin types I/II (sun sensitive/tan poorly) are at greater risk than skin types III/IV (sun tolerant/tan well). Studies in mice demonstrate that ultraviolet radiation (UVR)-induced suppression of cell-mediated immune function plays an important role in the development of skin cancer and induces a susceptibility to infec...

of both lower limbs, suggesting subcutaneous inflammation (like the groove sign; FIGURE 1C). Thus, subcutaneous panniculitis was considered the cause of fever and erythema. Blood tests revealed increased levels of lactate dehydrogenase (399 IU/l) and soluble interleukin-2 receptor (3563 U/ml). Contrast-enhanced computed tomography of the chest, abdomen, pelvis, and lower limbs revealed diffuse,...

The aim of the present study was to compare the effectiveness and the safety of different topical agents (glycolic acid, mandelic acid, and grape juice acid mixture) in skin exfoliation by objective instrumental methods. To evaluate the exfoliating effects of these substances, a new experimental in vivo protocol based on DHA (dihydroxyacetone)-induced skin pigmentation was used. Skin acceptabil...

Lyme disease is caused by the spirochete Borrelia burgdorferi. Depending on the stage of illness, infection may be limited to the skin or involve the cardiac, nervous and musculoskeletal systems. Herein, we report a case of Lyme disease in a 23-year-old woman from North of Iran (Mazandaran) in early-localized stage of erythema chronicum migrans. The diagnosis was confirmed by the presence of se...

The purpose of this study was to determine the effects of skin pigmentation regarding Near Infrared Spectroscopy (NIRS) tissue oxygen saturation values (StO2). The study examined NIRS values in individuals with varying skin pigmentation on the anterior compartment of the lower leg and volar forearm to determine if correlation exists among three NIRS devices, the EQUANOX, Casmed, and INVOS. Skin...

Rosacea is a chronic inflammatory skin condition with neurovascular components. Calcitonin gene-related peptide (CGRP) hypothesized to play key role in the pathophysiology of rosacea, but evidence remains limited. In this study, we aimed describe effect CGRP monoclonal antibodies (MAbs) on rosacea signs and symptoms. We conducted retrospective cohort study at single academic center from 2016-20...

Background: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. Purpose: To review the different kinds of management for all subtypes. Methods: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. Results: Flushing...

The rosehip seed oil (RHO), obtained from different plant species of the genus Rosa, is one of the compounds used empirically for cosmetic improvement of skin scarring. Despite its widespread use in clinical practice, there are few studies evaluating the activity of this compound on the clinical course of cutaneous scars. The aim of this study was to determine the effect of Repavar® rosehip oil...

Background: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. Purpose: To review the different kinds of management for all subtypes. Methods: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. Results: Flushing...

In England, over 275,000 people per year are diagnosed with cancer and more than half of these receive radiotherapy as part of their treatment (Delaney et al, 2005). One of the most common side-effects arising from radiotherapy are skin reactions, which can range from being mild (dull erythema and tightening of the skin) to severe (moist desquamation with open wounds and oedema). Some patients ...