During reaching or drawing, the primate cortex carries information about the current and upcoming position of the hand. Researchers have decoded hand position, velocity, and acceleration during center-out reaching or drawing tasks from neural recordings acquired invasively at the microscale and mesoscale levels. Here we report that we can continuously decode information about hand velocity at t...

Recent animal experiments indicate a critical role for opening of the blood-brain barrier (BBB) in the pathogenesis of post-traumatic epilepsy (PTE). This study aimed to investigate the frequency, extent, and functional correlates of BBB disruption in epileptic patients following mild traumatic brain injury (TBI). Thirty-seven TBI patients were included in this study, 19 of whom suffered from P...

Deficits in cognitive control are a hallmark characteristic of depression, however less is known about the degree to which they persist beyond symptom remission and might contribute to symptom recurrence in remitted individuals (rMDD). Evidence indicates that stress interferes with cognitive control, highlighting a potential mechanism by which stress precipitates depression relapse. Therefore, ...

Acute alcohol intake is known to enhance inhibition through facilitation of GABA(A) receptors, which are present in 40% of the synapses all over the brain. Evidence suggests that enhanced GABAergic transmission leads to increased large-scale brain connectivity. Our hypothesis is that acute alcohol intake would increase the functional connectivity of the human brain resting-state network (RSN). ...

OBJECTIVE One of the most widely used approaches in electroencephalography/magnetoencephalography (MEG) source imaging is application of an inverse technique (such as dipole modelling or sLORETA) on the component extracted by independent component analysis (ICA) (sensor-space ICA + inverse technique). The advantage of this approach over an inverse technique alone is that it can identify and loc...

Flexible response adaptation and the control of conflicting information play a pivotal role in daily life. Yet, little is known about the neuronal mechanisms mediating parallel control of these processes. We examined these mechanisms using a multi-methodological approach that integrated data from event-related potentials (ERPs) with structural MRI data and source localisation using sLORETA. Mor...

localization of sources in patients with focal seizure has recently attracted many attentions. in the severe cases of focal seizure, there is a possibility of doing neurosurgery operation to remove the defected tissue. the prosperity of this heavy operation completely depends on the accuracy of source localization. to increase this accuracy, this paper presents a new weighted beamforming method...

Schizophrenia is one of the most devastating of all mental illnesses, and has dimensional characteristics that include both positive and negative symptoms. One problem reported in schizophrenia patients is that they tend to show deficits in face emotion processing, on which negative symptoms are thought to have stronger influence. In this study, four event-related potential (ERP) components (P1...

Title of Document: NONINVASIVE NEURAL DECODING OF OVERT AND COVERT HAND MOVEMENT Trent J. Bradberry, Doctor of Philosophy, 2010 Directed By: Associate Professor José L. Contreras-Vidal, Department of Kinesiology, Graduate Program in Neuroscience and Cognitive Science, Fischell Department of Bioengineering It is generally assumed that the signal-to-noise ratio and information content of neural d...