bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

Leiomyosarcomas are spindle cell tumors showing smooth muscle differentiation. Until recently, most gastrointestinal stromal tumors (GIST) were also classified as smooth muscle tumors, but now GISTs are recognized as a separate entity, defined as spindle cell and/or epithelioid tumors localized in the gastrointestinal tract. Using microarray-based comparative genomic hybridization (array CGH), ...

BACKGROUND AND AIM Gliosarcoma (GS) is an uncommon malignant tumor of the brain, consisting of malignant glial, usually a glioblastoma (GB), as well as sarcomatous component; the latter is usually in the form of fibrosarcoma. We report a series of 10 GSs with prominent smooth muscle component, which is a rare occurrence. SETTINGS AND DESIGN Out of a series of 225 cases of GB admitted in our h...

Glomus tumor (GT) of the stomach is a rare mesenchymal tumor. There have been few detailed studies on these tumors. A total of 1894 cases of resected gastric mesenchymal tumors were collected and eleven confirmed gastric GTs were studied. The clinical, pathological, immunohistochemical, ultrastructural and molecular characteristics of the tumors were analyzed through a retrospective study. Hist...

In recent years, a group of tumors that have been designated "perivascular epithelioid cell tumors" (PEComa) have been reported with increasing frequency from a wide variety of anatomic locations. The uterus and retroperitoneum appear to be the most frequent sites of origin for these lesions. PEComas belong to an identically named family of tumors comprised of conventional angiomyolipomas, clea...

objective(s): in the present study, the effect of tissue incubation with propranolol on functional antagonism of zataria multiflora boiss (z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined.  materials and methods: the effects of three concentrations of aqueous-ethanolic extract, 10 nm atropine, and saline on muscarinic receptors were tested on incubated tracheal smoo...

Smooth muscle tumors of the uterus are rare in rats. In our colony such tumors have never been found. It is true, however, that only a fraction of the colony has been allowed to reach extreme old age before autopsy. Bullock and Curtis (1) have data on over 2450 rats with cysticercus tumors and 489 rats with independent or primary spontaneous tumors. In the latter group there were 48 uterine tum...

BACKGROUND/AIM Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines. Despite this fact, their pathogenesis is still poorly understood. The aim of this study was to determine immunocytochemical characteristics of smooth muscle cells and connective tissue components of submucosal myomas of the uterus. MET...

Cytokeratins are a set of 19 proteins that together constitute the class of intermediate filament protein expressed by epithelial cells and tumors. Using a panel of 9 different monoclonal anti-cytokeratin antibodies, the authors have performed immunocytochemistry on methanol-fixed, frozen sections and methacarn-fixed, paraffin-embedded tissue of human myometrial specimens. Anomalous cytokeratin...

BACKGROUND AND AIM: Solitary fibrous tumor (SFT) is a quite uncommon tumor that commonly occurs in the pleura but occasionally involves an oral cavity. We are reporting this rare case in the oral cavity. The diagnosis depends on microscopic and immunohistochemical features. Patients with these tumors can be carefully treated with local excision, but tumors with...