نتایج جستجو برای: sod2
تعداد نتایج: 1638 فیلتر نتایج به سال:
Acquired resistance of cancer cells to anticancer drugs or ionizing radiation (IR) is one of the major obstacles in cancer treatment. Pancreatic cancer is an exceptional aggressive cancer, and acquired drug resistance in this cancer is common. Reactive oxygen species (ROS) play an essential role in cell apoptosis, which is a key mechanism by which radioor chemotherapy induce cell killing.Mitoch...
سابقه و هدف: بروز تنش خشکی سبب ایجاد اختلالات متابولیسمی در سلولهای گیاهی میگردد که میتوان به افزایش تولید گونههای فعال اکسیژن بهعنوان یکی از عوامل اصلی اختلالات متابولیسمی سلول اشاره کرد. گیاهان برای مقابله با تنش اکسیداتیو ایجاد شده، دارای سیستم دفاعی با کارایی بالایی هستند که میتواند رادیکالهای آزاد را از بین برده و یا خنثی کنند. بنابراین در شرایط تنش خشکی، فعالیتهای بالای آنزیمهای ...
PoZymorphism. An RFLP was detected in the superoxide dismutase 2 (SOD2) locus of swine using the restriction enzyme StuI. Source and Description of Probe. An 827-bp human cDNA clone for SOD2 was excised from the EcoRI site of plasmid phMnSOD4 (Xiang et al., 1987). Method of Detection. DNA was isolated from blood, digested with StuI, separated by agarose gel electrophoresis, and transferred ...
BACKGROUND AND OBJECTIVES The discovery of different podocyte autoantibodies in membranous nephropathy (MN) raises questions about their pathogenetic and clinical meaning. This study sought to define antibody isotypes and correlations; to compare levels in MN, other glomerulonephritides, and controls; and to determine their association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & ...
BACKGROUND Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased scavenging of reactive oxygen species in the vascular wall are major contributors to atherogenesis. We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and ...
BACKGROUND Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated enzymatic antioxidant system. Besides, the mitochondrial DNA (mtDNA) haplogroups are associated with the OA disease. Thus, the main goal of this work is to assess the incidence of the mtDNA ha...
Glutathione S-transferases (GSTs), superoxide dismutase 2 (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase T1 (GSTT1)-wt patients with varicocele may e...
Oxidative stress as a contributor to neuronal death during prion infection is supported by the fact that various oxidative damage markers accumulate in the brain during the course of this disease. The normal cellular substrate of the causative agent, the prion protein, is also linked with protective functions against oxidative stress. Our previous work has found that, in chronic prion infection...
Bmi1 (B-cell-specific Moloney murine leukemia virus insertion site 1) had been found to involve in self -renewal of stem cells and tumorigenesis in various malignancies. The purpose of this study is to evaluate the role of Bmi1 in the development of tongue squamous cell carcinoma (TSCC) and its functional effect on the migration and invasion of TSCC. Initially, immunohistochemistry revealed tha...
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