Breast cancer is a common malignancy in women all over the world and novel therapeutic approaches are required for the treatment of patients who become refractory to conventional therapies. Thyroid cancer is being treated successfully with radioiodine since many years. The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protei...

The molecule of the title compound, [Na(C(13)H(11)N(3)O)(2)(CH(3)OH)(2)]I, is non-planar, with the Na atom chelated by the O atoms and the N atoms of two N'-(3-pyridylmethyl-ene)benzohydrazide ligands and both O atoms of two methanol ligands. The asymmetric unit consists of one half-mol-ecule. The Na atom is located on a crystallographic centre of inversion. The six-coordinate Na atom adopts a ...

PURPOSE Sodium iodide symporter (NIS) expression in breast cancer (BC) tissues suggests the possibility of using radioiodine for diagnostic and therapeutic purposes. This study evaluated NIS protein expression in primary BC samples and its association with BC prognostic markers and thyroid functional parameters. METHODS Fifty-six breast tissue samples from 52 operated women (41 BC, 11 benign ...

Ab initio configuration interaction calculations of the electronic binding energies, spin–orbit coupling matrix elements and transition dipole moments of NaI are presented. The results are used to construct adiabatic and diabatic representations of the 0 molecular states relevant to predissociation. The dynamics of photopredissociation is elucidated by multichannel time-dependent wave packet pr...

UNLABELLED Transfer of the human sodium iodide symporter (hNIS) has been proposed as a new principle of cancer gene therapy. This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions. METHODS Using a bicistronic retroviral vector for the transfer of the hNIS and the hygromycin resistance gene, hNIS-expressing rat thy...

Iodide is an important regulator of thyroid activity. Its excess elicits the Wolff-Chaikoff effect, characterized by an acute suppression of thyroid hormone synthesis, which has been ascribed to serum TSH reduction or TGF-beta increase and production of iodolipids in the thyroid. These alterations take hours/days to occur, contrasting with the promptness of Wolff-Chaikoff effect. We investigate...

Sodium hydride (NaH) is widely used as a Brønsted base in chemical synthesis and reacts with various Brønsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows Na...