The present studies were designed to explore the possible mode of protective and ulcer healing actions of sucralfate by examining its effect on gastroduodenal bicarbonate secretion by isolated amphibian mucosa. Luminal sucralfate (0.5 g/l) significantly increased bicarbonate secretion by fundic and antral mucosa without influencing transmucosal potential difference. Significant stimulation of d...

Introduction Hyperpolarized (HP) [1-C]pyruvate has been shown to be metabolized to [C]bicarbonate and other products both in vivo and in isolated perfused hearts. The appearance of a [C]bicarbonate signal following an injection of hyperpolarized [1-C]pyruvate reflects the activity of pyruvate dehydrogenase (PDH) in heart. In some metabolic circumstances, the [C]bicarbonate signal is low and con...

Previous studies with propionyl coenzyme A carboxylase and with phosphoenolpyruvate carboxylase using ‘*O-labeled bicarbonate have indicated that bicarbonate is the reactive species in these fixations of “C02.” We have investigated the species of CO:! in reactions catalyzed by pyruvate carboxylase, P-enolpyruvate carboxykinase, and P-enolpyruvate carboxytransphosphorylase. Since propionyl-CoA c...

PURPOSE It has been reported that the addition of epinephrine and/or bicarbonate to local anesthetic enhances the depth of epidural blockade and that initial partial bolus injection results in greater caudal spread. We evaluated the anesthetic effects of lidocaine with epinephrine and/or bicarbonate injected into the epidural space by bolus or catheter injection. METHODS Forty-four patients u...

Mammalian sperm cells are activated prior to fertilization by high bicarbonate levels, which facilitate lipoprotein-mediated cholesterol efflux. The role of bicarbonate and cholesterol acceptors on the cholesterol organization in the sperm plasma membrane was tested. Bicarbonate induced an albumin-independent change in lipid architecture that was detectable by an increase in merocyanine stainin...

In the tropical fresh water fish, Synbranchus marmoratus, transition from water breathing to air breathing, induced by reduction of oxygen partial pressure (PO2) in the environmental water below 16 mmHg, causes a considerable rise in the arterial partial pressure of carbon dioxide (PCO2), from 5.6 to 26 mmHg on the average (half time of the rise between 2 and 6.5 h). The associated fall in arte...

S INCE the extensive studies of Pitts and coworkers (1-3) defined the characteristics of bicarbonate reabsorption in the normal subject, very little additional information has appeared concerning the nature of this transport system or its regulation. It was suggested then (2) that a dual process existed for the reabsorption of bicarbonate. A specific transport system in the proximal tubule was ...

Rat liver microsomal glucose 6-phosphate phosphohydrolase has been shown to possess two further catalytic activities: the hydrolysis of inorganic pyrophosphate to orthophosphate and a pyrophosphate-glucose phosphotransferase activity. Physiological concentrations of bicarbonate ion (10 to 50 mM) have been found to inhibit all three activities. A detailed kinetic analysis of the nature and exten...

BACKGROUND Radiographic contrast media exposition can cause acute renal function impairment. There is limited and conflicting evidence that hydration with sodium bicarbonate prevents contrast-induced nephropathy (CIN) in patients undergoing cardiac catheterization. OBJECTIVE The present study was aimed at determining whether sodium bicarbonate is superior to hydration with saline to prevent n...

1. Distal blockade by simultaneous administration of ethacrynic acid and chlorothiazide was performed in healthy subjects whose extracellular fluid was expanded by iso-osmotic sodium chloride or bicarbonate. The results obtained were compared with those from non-expanded subjects (Ardaillou & Fillastre, 1969). 2. By this technique urine approximates in composition to proximal tubular fluid and ...