AIM To prospectively evaluate the efficacy of sofobuvir (SOF) in hepatitis C patients infected with hepatitis C virus (HCV) genotype 3 in Pakistan. METHODS The present study was performed with the coordination of gastroenterology and pathology departments of Shalamar Hospital Lahore from August 2014 to May 2016. The total number of patients included in this study was 1375 and all of them were...

Short treatment duration of ledipasvir/sofosbuvir (LDV/SOF) has been successfully used to treat hepatitis C virus (HCV) genotype 1 infection in treatment-naive noncirrhotic patients with viral loads (VLs) under 6 million IU/mL. However, this short duration has not been studied in renal transplant recipients (RTRs), a patient population on lifelong immunosuppression. Here, we describe 3 RTRs who...

We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both se...

The aim of the article is to find out requirements professional combat activity servicemen Special Operations Forces Armed Ukraine their physical and psychological preparedness. Methods: theoretical analysis generalization scientific methodical literature, Internet data networks, documentary method. On basis open literary sources, peculiarities activities (SOF) NATO member countries have been c...

La combinación de sofosbuvir-velpatasvir (SOF/VEL) es una terapia antiviral acción directa que está autorizada y disponible en México. Esto hace la evaluación respuesta virológica sostenida (RVS) 12 semanas después del tratamiento, por medio realización revisión multicentro el mundo real, sea tarea relevante. Se efectuó retrospectiva los registros 241 casos pacientes atendidos 20 hospitales Méx...

The use of special operations forces (SOF) in war fighting and peace keeping efforts has increased dramatically in recent decades. A scientific understanding of the reason for this increase would provide guidance as to the contexts in which SOF can be used to their best effect, and when conventional forces are better suited. Ashby’s law of requisite variety provides a scientific framework for u...

This work proposes a methodology to measure the holding time in nanometer technologies. In nanotechnologies, the behavior of Stuck-Open Fault (SOF) is more affected by the high leakage currents and low signal node capacitance. Therefore, evaluate the holding time is very important because depending on the operation frequency that the circuit is analyzed, some pair of vectors cannot be used to d...

Composites have revolutionized the concept in asthetic dentistry. Proper finishing and polishing of composites are important aspects of clinical restorative procedures that enhance both asthetics and the longevity of the restoration. A number of finishing and polishing devices are available, but to decide the efficacy of various materials is still a challenge to the dentists or clinicians. Henc...

A new concept of spectral fuzzy sets ha~ been introduce<.l for dealing with the uncertainty in ~ubjective assignment of membership value to the clements of a fuzzy ~et. The concept is characterized by a ~el of membership functions reflecting an individual's (or several individuals') opinion. The uncertainty due to spcclralness has becn explaine<.l. To <.Iemon­ stratc [he necessity and effective...

Introduction: Superior Orbital Fissure (SOF) is located between the roof and lateral wall of orbit. SOF exhibits complex anatomy because abundant neurovascular structures running through or near it connects orbit with cranial cavity. Variant anatomy, in terms morphology well documented literature, but data regarding morphometrical study limited. Aim: To provide a baseline on morphometry SOF. Ma...