the aim of the present study was to investigate the effect of hiit run on pgc-1α gene expression in fast & slow twitch muscles of healthy male  rats. for this purpose, 12 male wistar rats divided into two groups: contorol (n=6) and exercise (n=6) , respectively. intense interval training was consists of five days and a total of eight weeks,  that was formed the three frequencies ( 90 to 100% vo...

BACKGROUND The relationship between decreased activity/neuropathic pain and gene expression alterations in soleus muscle has remained elusive. OBJECTIVES In this experimental study, we investigated the effects of decreased activity in neuropathic pain form on Cyclin-Dependent Kinase 5 (CDK5) and Glycogen Synthase Kinase-3 β (GSK-3β) gene expression in soleus muscle of rats. MATERIALS AND ME...

Changes in alphaB-crystallin content in adult rat soleus and extensor digitorum longus (EDL) were examined after 8 wk of 3,5, 3'-triiodothyronine (T(3)) and propylthiouracil (PTU) treatments. Cellular distributions of alphaB-crystallin expression related to fiber type, and distribution shifts with these treatments were also examined in detail from the gray level of reactivity to specific anti-a...

Duchenne muscular dystrophy (DMD) induces sarcolemmal mechanical instability and rupture, hyperactivity of intracellular calpains, and proteolytic breakdown of muscle structural proteins. Here we identify the two sarcomeric tropomodulin (Tmod) isoforms, Tmod1 and Tmod4, as novel proteolytic targets of m-calpain, with Tmod1 exhibiting ∼10-fold greater sensitivity to calpain-mediated cleavage tha...

Acetylcholinesterase (AChE) expression in fast rat muscles is approximately fourfold higher than in slow muscles. We examined whether different muscle activation patterns are responsible for this difference and whether the calcineurin signaling pathway is involved in AChE regulation. The slow soleus and fast extensor digitorum longus (EDL) muscles were directly or indirectly stimulated by a ton...

An isotopic method was used in conscious rats to determine the roles of glucose transport and the transsarcolemmal glucose gradient (TSGG) in control of basal and insulin-stimulated muscle glucose uptake. Rats received an intravenous 3- O-[3H]methylglucose (3- O-[3H]MG) infusion from -100 to 40 min and a 2-deoxy-[3H]glucose infusion from 0 to 40 min to calculate a glucose metabolic index (Rg). ...

Pencek, R. Richard, Alessandra Bertoldo, Julie Price, Carol Kelley, Claudio Cobelli, and David E. Kelley. Dose-responsive insulin regulation of glucose transport in human skeletal muscle. Am J Physiol Endocrinol Metab 290: E1124–E1130, 2006. First published January 3, 2006; doi:10.1152/ajpendo.00598.2004.—Glucose transport is regarded as the principal rate control step governing insulinstimulat...