In polarized mature neurons, the asymmetrical distribution of proteins between axonal and somatodendritic plasma membrane (PM) domains may be maintained by a diffusion barrier at the axon-soma boundary. At the boundary, a complex containing membrane-associated and cytoskeletal proteins is formed, anchoring axonal membrane proteins and indirectly hindering the diffusion of other membrane protein...

We examined how hippocamal CA1 neurons process complex time-varying inputs that dendrites are likely to receive in vivo. We propose a functional model of the dendrite-to-soma input/output relationship that combines temporal integration and static-gain control mechanisms. Using simultaneous dual whole cell recordings, we injected 50 s of subthreshold and suprathreshold zero-mean white-noise curr...

The adult rat posterodorsal medial amygdala (MePD) is sexually dimorphic in regional volume and neuronal soma size, both of which are larger in males than in females. This sexual dimorphism is entirely dependent on adult circulating levels of testicular androgens, and both androgen and estrogen treatment can masculinize MePD structure. We examined male rats that are rendered androgen-insensitiv...

One type of light-induced response (photopic L-type S-potential)recorded from isolated carp (Cyprinus carpio) retinas was identified by its spectral response and later confirmed by morphological localization of the recorded sites ionophoretically marked by a fluorescent dye, Lucifer yellow. Such L-type S-potentials could be recorded from the soma and from the axon terminal of external horizonta...

Neurons in the heart ganglion of the mantis shrimp (a stomatopod crustacean) are functionally tightly linked together. The extracellular action potential from the whole trunk very often shows a complex form, but the response is all-or-none to the applied stimulus, indicating that the excitation in one neuron spreads very rapidly to all others. Application of isotonic MgCl(2) solution or repetit...

Bu çalışmada Soma, Çatalağzı ve Tunçbilek termik santrallerinden elde edilen uçucu küllerin, Kunduzlar toprak barajının çekirdek kısmının inşa edildiği ince taneli zeminin kompaksiyon dayanım özellikleri üzerindeki etkileri incelenmiştir. Zemine %5, %10, %15, %20, %25 %30 oranlarında kül katkıları eklenerek optimum su muhtevaları belirlenmiştir. Optimum muhtevalarında hazırlanan numuneler kesme...

UNLABELLED Autophagy is an essential degradative pathway that maintains neuronal homeostasis and prevents axon degeneration. Initial observations suggest that autophagy is spatially regulated in neurons, but how autophagy is regulated in distinct neuronal compartments is unclear. Using live-cell imaging in mouse hippocampal neurons, we establish the compartment-specific mechanisms of constituti...