نتایج جستجو برای: somatic cell nuclear transfer
تعداد نتایج: 2125338 فیلتر نتایج به سال:
In this review, we discuss the recent advances in somatic cell nuclear transfer (NT) in sheep, cattle, goats, swine and rabbits. Numerous advances have been reported as this technique has developed over the last five years. In the first part of this review, we describe the reported data pertaining to each of the species mentioned above. Theories are offered to explain the different results seen...
After historic experiments by Briggs and King (Briggs and King, 1957; Briggs and King, 1952), animal cloning has emerged as a key approach to explore functional changes in the nuclear genome during differentiation (Gurdon, 1974; Gurdon, 1999; Kikyo and Wolffe, 2000; Rideout et al., 2001; Solter, 2000). Studies in amphibians have revealed that the potential of the nucleus to direct normal embryo...
Polyploidy has many advantages over diploidy, such as rapid growth, sterility, and disease resistance, and has been extensively applied in agriculture and aquaculture. Though generation of new polyploids via polyploidization has been achieved in plants by different ways, it is comparatively rare in animals. In this article, by a chemical compound, SP600125, polyploidization is induced in fish c...
BACKGROUND Over the past several years, mammals have been successfully cloned by either the splitting of an early stage embryo or nuclear transfer of adult somatic cells (NT) into oocytes. Although it has been 15 years since the generation of the first cloned mammals from somatic cells by NT, the success rate for producing live offspring by this technique is low regardless of the cell type and ...
The low success rate of somatic nuclear transfer (NT) is hypothesized to be mainly due to functional defects in the trophoblast cell lineage rather than the inner cell mass (ICM); this hypothesis, however, remains to be tested directly. Here we separated the ICMs from cloned blastocysts and aggregated the cloned ICM with two fertilization-derived (FD) tetraploid (4N) embryos. We found that the ...
Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES cell morphology and cell surface markers and were capable of differentiating into embryoid bodies...
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