Introduction and purpose: Acromegaly is a rare disease which occurs with the frequency of 0.2-1.1 cases per 100 000 patients year. The main cause excess level growth hormone (GH) stimulates liver to insulin-like factor type 1 (IGF-1) secretion. IGF-1 leads tissues overgrowth. In addition, acromegalic suffer from many comorbidities, such as: cardiovascular, endocrinological, neoplastic musculosk...

Background Osteoarthritis of the knee, together with that hip, is most serious disease osteoarthritis. Long considered a benign disease, gonarthrosis nevertheless associated significant morbidity. Objectives To assess prevalence co-morbidities in patients and to their impact on pain, functional radiographic progression. Methods Our study involved gonarthrosis. Comprehensive comorbidity screenin...

somatic embryogenesis was initiated in c. sativus l. from shoot meristems on ls medium containing bap (2×10-5 m)+naa (2×10-5 m). various stages of somatic embryogenesis were observed in the same medium and the development was asynchronous. somatic embryo development proceeded through well recognized sequences (globular to embryoids) with clearly discernible bipolar regions. matured embryos coul...

Background: Chronic diseases including hypertension have become a global burden in the older population and are associated with increased mortality and decreased quality of life. The persistence of these diseases could increase the comorbidities and impact older patients who need palliative care services to manage the symptom and improve their quality of life.  This study aims to determine the ...