OBJECTIVES For most gout patients, excruciatingly painful gout attacks are the major clinical burden of the disease. The goal of this study was to assess the association of frequent gout flares with healthcare burden, and to quantify how much lower gout-related costs and resource use are for those with infrequent flares compared to frequent gout flares. DESIGN Retrospective cohort study. SE...

BACKGROUND The evolution of rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) is marked by flares, although their frequency is unclear. Flares may impact physical activity. Activity can be assessed objectively using activity trackers. The objective was to assess longitudinally the frequency of flares and the association between flares and objective physical activity. METHODS This ...

Natural gas is the most popular fossil fuel in the current era and future as well. Natural gas is existed in underground reservoirs so it may contain many of non-hydrocarbon components for instance, hydrogen sulfide, nitrogen and water vapor. These impurities are undesirable compounds and cause several technical problems for example, corrosion and environment pollution. Therefore, these impurit...

Context. Previously detected in only a few gamma-ray bursts (GRBs), X-ray flares are now observed in ∼ 50% of Swift GRBs, though their origins remain unclear. Most flares are seen early on in the afterglow decay, while some bursts exhibit flares at late times of 104 to 105 seconds, which may have implications for flare models. Aims. We investigate whether a sample of late time (& 1 × 104 s) fla...

The research paper provides the results of investigation of “Sour-milk feed supplement” for piglets based on natural association of microorganisms Lactomyces tibeticus. It was found that probiotic microorganisms that compose sour-milk feed supplement withstand the adverse actions of gastrointestinal tract and can be easily acclimatized in the intestinal tract of piglets. Administration of sour-...

We used a next-generation high-throughput sequencing platform to resequence the Xinguowei and Shouxing melon cultivars, the parents of Fengwei melon. We found 84% of the reads (under a coverage rate of "13×") placed on the reference genome DHL92. There were 2,550,000 single-nucleotide polymorphisms and 140,000 structural variations in the two genomes. We also identified 1,290 polymorphic genes ...

The two 5GHz VLBI (Very Long Baseline Interferometry) observations (1996 June and 1997 November) presented in this paper, combined with several former VLBI observations at 8.4GHz and 5GHz, suggest that the radio flares of the blazar PKS 0420−014 can be divided into two classes according to their geometric origins in 5 or 8.4GHz VLBI maps and the properties of light curves. One class of flares, ...

Kaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder. Human (h) IL-6 and a KSHV-encoded homolog, viral IL-6, have been hypothesized to contribute to its pathogenesis, but their relative contributions to disease activity is not well understood. We prospectively characterized KSHV viral load (VL), viral (v) and hIL-6...

We report the discovery of fast (∼ 100 sec) 2.2 µm flares from the micro-quasar GRS 1915+105, which are superimposed on longer (∼ 30 min), brighter flares corresponding to episodes of jet formation. The number and strength of the sub-flares in each bright flare varies, and does not seem to correlate in any obvious way with the underlying light curve or with changes in the X-ray emission. Howeve...