Leghemoglobin may be isolated from soybean root nodules as a complex, leghemoglobin a-X of ferric leghemoglobin with a low molecular weight ligand X. That complex dissociates at neutral or alkaline pH and the ligand X may be separated from free leghemoglobin by ultrafiltration. The complex is regenerated by combining ferric leghemoglobin with X. The affinity of ferrous leghemoglobin for X is ve...

iron oxide is an important biological agent that has a key role in medical processes; however, the mechanism whereby it provides iron for human and animal cells and its biological uses remains unclear. we aimed to evaluate the effects of oral iron oxide on serum iron status and compare the results with those of iron sulfate as a reference salt. fifteen adult rabbits were divided into 3 groups o...

The concentrations of ferrous and ferric ions change dramatically during the course of the batch experiments usually performed to study the kinetics of the bacterial oxidation of ferrous ions and sulfide minerals. This change in concentration of the iron species during the course of the experiment often makes it difficult to interpret the results of these experiments, as is evidenced by the lac...

Porphyria cutanea tarda (PCT) is characterized biochemically by excessive hepatic synthesis and urinary excretion of uroporphyrin I. Clinical evidence has implicated iron in the pathogenesis of PCT. The synthesis of the normally occurring isomer of uroporphyrin, namely uroporphyrin III, from porphobilinogen (PBG) requires two enzymes; uroporphyrinogen I synthetase and uroporphyrinogen III cosyn...

Cysteine plays a key role as a metal ligand in metalloproteins. In all well-recognized cases, however, it is the anionic cysteinate that coordinates. Several cysteinate-ligated heme proteins are known, but some fail to retain thiolate ligation in the ferrous state, possibly following protonation to form neutral cysteine. Ligation by cysteine thiol in ferrous heme proteins has not been documente...

A 71-year-old man with a history of hypertension and dyslipidemia underwent emergency department due to dyspnea and chest discomfort. Chest radiography revealed cardiomegaly and signs of pulmonary congestion, whereas the ECG was consistent with recent myocardial injury (antero-septal and lateral). Cardiac catheterization showed a huge right coronary artery (RCA) with left coronary artery collat...