BACKGROUND Human spermatogenesis is regulated by complex networks, and estrogens are recognized as one of the significant regulators of spermatogenesis. We tested the associations between variants of estrogen-related genes and semen parameters. METHODS We performed genotyping for genetic variants of estrogen-related genes and quantitative trait analysis of fertile and infertile men with well-...

Epididymal secreted proteins promote sperm maturation and fertilizing capacity by interacting with sperm during passage through the epididymis. Here we investigate the molecular basis of sperm maturation by isolating cDNA clones for novel epididymis-specific expressed sequences. Thirty-six novel cDNAs were isolated and sequenced from a subtracted Macaca mulatta epididymis library. The clones en...

Anopheles gambiae mosquitoes are major African vectors of malaria, a disease that kills more than 600,000 people every year. Given the spread of insecticide resistance in natural mosquito populations, alternative vector control strategies aimed at reducing the reproductive success of mosquitoes are being promoted. Unlike many other insects, An. gambiae females mate a single time in their lives ...

Oxidative stress plays a major role in the life of mammalian spermatozoa. These cells are professional generators of reactive oxygen species (ROS), which appear to largely derive from the sperm mitochondria. The oxidative stress created by these organelles appears to play a facilitatory role in driving the physiological changes associated with sperm capacitation. However when generated in exces...

The relationship of the hemipenis to the cloaca in copula and sperm storage and transport in the female oviduct were studied in Anolis carolinensis using light and scanning electron microscopy. During copulation, the hemipenis does not penetrate beyond the cloaca, but the two apical openings of the bifurcate sulcus spermaticus appose the openings of the oviducts from the cloaca. Sperm enter the...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Drevet in his commentary (1) responding to the practice recommendations for Sperm DNA Fragmentation (SDF) testing based on clinical scenarios by Agarwal et al. (2) elegantly discussed the biological effect of DNA fragmentation and its implications to the paternal contribution of the male gamete. The author goes fu...

BACKGROUND C. elegans male sexual behaviors include chemotaxis and response to hermaphrodites, backing, turning, vulva location, spicule insertion, and sperm transfer, culminating in cross-fertilization of hermaphrodite oocytes with male sperm. The LOV-1 and PKD-2 transient receptor potential polycystin (TRPP) complex localizes to ciliated endings of C. elegans male-specific sensory neurons and...

primary antibody was omitted. The slides were observed, and images were acquired with a confocal LSM710 microscope and an Axioplan microscope (both from Zeiss, Göttingen, Germany). Tau immunostaining was detected in all smeared spermatozoa (Figure 1a). The Tau protein was located in the sperm midpiece. In testicular tissue, Tau immunoreactivity was observed in both spermatocytes and spermatids ...