The overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. Acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. It would be of particular importance to interrupt the progress of events h...

spinal cord injury (sci) in humans remains a devastating and incurable disorder. a very important obstacle in axonal regeneration after spinal cord injury is astroglial scaring. the use of self-assembling peptide nanofiber, a hydrogel mimicking extracellular matrix, has been suggested as a scaffold for spinal cord regeneration and inhibition of astrogliosis. however, neurogenesis potential of l...

introduction: despite the vast number of surveys, no consensus has been reached on the optimum timing of spinal decompression surgery. this systematic review and meta-analysis aimed to compare the effects of early and late spinal decompression surgery on neurologic improvement and post-surgical complications in patients with traumatic spinal cord injuries. methods: two independent reviewers car...

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord inj...

spinal cord injury (sci) results in up regulation and/or down regulation of several genes that may affect neuronal death and subsequent loss of motor function and also neuropathic pain. to expand a practical therapy, it is essential to recognize the specific molecular pathways altered as a function of time after spinal cord injury. this will help to develop strategies for positive manipulation ...

Spinal cord injury (SCI) refers to the damage of spinal cord's structure and function due to a variety of causes. At present, many scholars have confirmed that apoptosis is the main method of secondary injury in spinal cord injury. In view of understanding the function of PI3K/Akt pathway on spinal cord injury, this study observed the temporal variation of key molecules (PI3K, Akt, p-Akt) in th...

STUDY DESIGN A retrospective review was performed to identify patients at risk for secondary neurologic deterioration after complete cervical spinal cord injury. OBJECTIVE To examine the causes of early neurologic deterioration in patients with complete spinal cord injury at a regional spinal cord injury center. SUMMARY OF BACKGROUND DATA After complete spinal cord injury, neurologic deteri...

STUDY DESIGN A prospective analysis evaluating neurologic outcome after early versus late surgery for cervical spinal cord trauma. OBJECTIVES The study was conducted to determine whether neurologic and functional outcome is improved in traumatic cervical spinal cord-injured patients (C3-T1, American Spinal Injury Association grades A-D) who had early surgery (<72 hours after spinal cord injur...

STUDY DESIGN  Retrospective cohort study. OBJECTIVES  To find out: (1) if the energy of trauma (high and low) influence the outcome after cervical spinal cord injury; (2) if time to decompression and degree of injury (complete and incomplete) influence the outcome after high- and low-energy cervical spinal cord injury. METHODS  Twenty-one consecutive patients with low-energy cervical spinal...