Preparation of iron salts Fe + 3 Fe+2 This study aims to prepare super-magnetic nanoparticles coated with chitosan-CS SPIONs in an easy and inexpensive chemical way, which is the method co-precipitation mediated aqueous solution mixing it a chitosan CS dissolved dilute citric acid 1 % precipitation this mixture NaOH sodium citrate as surfactant inside closed system using inert atmosphere for ni...

Understanding how nanoparticles may affect immune responses is an essential prerequisite to developing novel clinical applications. To investigate nanoparticle-dependent outcomes on immune responses, dendritic cells (DCs) were treated with model biomedical poly(vinylalcohol)-coated super-paramagnetic iron oxide nanoparticles (PVA-SPIONs). PVA-SPIONs uptake by human monocyte-derived DCs (MDDCs) ...

In this work, we report on the fabrication of nanocomposites based superparamagnetic iron oxide nanoparticles (SPIONs) in combination with hydroxyapatite (HAp) as a platform for drug delivery and magnetic hyperthermia application. First, influence experimental conditions such co-precipitant, bath temperature, pH morphology properties SPIONs was investigated. Then, particles were coated layer fu...

Erectile dysfunction (ED) is a major complication of diabetes, and many diabetic men with ED are refractory to common ED therapies. Adipose tissue-derived stem cells (ADSCs) have been shown to improve erectile function in diabetic animal models. However, inadequate cell homing to damaged sites has limited their efficacy. Therefore, we explored the effect of ADSCs labeled with superparamagnetic ...

Much recent research on nanoparticles has occurred in the biomedical area, particularly in the area of superparamagnetic iron oxide nanoparticles (SPIONs); one such area of research is in their use as magnetically directed prodrugs. It has been reported that nanoscale materials exhibit properties different from those of materials in bulk or on a macro scale [1]. Further, an understanding of the...

Background Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods The conjugation of monoclonal antibody and nanopartic...

During the last decade, significant scientific research efforts have led to a significant growth in understanding of cancer at the genetic, molecular, and cellular levels providing great opportunities for diagnosis and treatment of cancer diseases. The hopes for fast cancer diagnosis and treatment were significantly increased by the entrance of nanoparticles to the medical sciences. Nanoparticl...

Microreactors have attracted wide attention in the nano- and biotechnology fields because they offer many advantages over standard liquid phase reactions. We report the development of a magnetic microreactor for reliable, fast and efficient surface functionalization of superparamagnetic iron oxide nanoparticles (SPIONs). A comprehensive study of the development process in terms of setup, loadin...

This work reports on the implementation of electrospinning (ES) as a facile route to encapsulate nano-engineered materials in a polystyrene (PS) matrix. We applied ES to co-encapsulate two kinds of nanoparticles, i.e., upconversion nanophosphors (UCNPs) and superparamagnetic iron oxide nanoparticles (SPIONs), in polystyrene (PS)-based microand nano-fibers (PSFs). This approach made it possible ...