The ability of a spatial population of cutaneous, Adelta, and C mechano-nociceptors to encode the location and intensity of a noxious, cutaneous indentation was examined using an isolated preparation in a rat model. Skin and its intact innervation were harvested from the medial thigh of the rat hindlimb and placed in a dish, with the corium side down, containing synthetic interstitial fluid. Th...

This paper presents sufficient conditions for the design of strictly positive real (SPR), fixed-order dynamic compensators. The primary motivation for designing SPR compensators is for application to positive real (PR) plants. When an SPR compensator is connected to a PR plant in a negative feedback configuration, the closed loop is guaranteed stable for arbitrary plant variations as long as th...

Monodisperse indium tin oxide nanoparticles (ITO NPs) with high crystallinity have been synthesized by the rapid thermal injection method and the seed-mediated growth method. We demonstrate that the surface plasmon resonance (SPR) frequencies of ITO NPs can be manipulated from 1,600 to 1,993 nm in near-infrared band by controlling the composition, size, and morphology. The doping Sn concentrati...

We fabricated a surface plasmon resonance (SPR) sensor using a hydrophilic polymer for the highly sensitive detection of 2,4,6-trinitrotoluene (TNT). The hydrophilic polymer was made from mono-2-(methacryloyloxy)ethylsuccinate (MES) and 2-hydroxyethylmethacrylate (HEMA) by surface-initiated atom transfer radical polymerization. The detection of TNT was carried out by displacement assay with the...

A surface plasmon resonance (SPR)-based biosensor was developed for specific detection of nine common respiratory virus, including influenza A and influenza B, H1N1, respiratory syncytial virus (RSV), parainfluenza virus 1-3 (PIV1, 2, 3), adenovirus, and severe acute respiratory syndrome coronavirus (SARS). The SPR biosensor was developed by immobilizing nine respiratory virus-specific oligonuc...

A single mode optical fiber probe employing surface plasmon resonance (SPR) as the transducing mechanism is described. The fiber has one end polished at an angle relative to the longitudinal axis and coated with a thin gold film. Diffraction of the guided mode out of the fiber core, after interaction with the metallized fiber tip, enables visual observation of a spatial SPR, the latter arising ...

Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based...

Surface plasmon resonance (SPR) imaging is a powerful technique for high-throughput, real-time, label-free characterization of molecular interactions in a microarray format. In this paper, we demonstrate SPR imaging with nanohole arrays illuminated by a laser source. Periodic nanoholes couple incident photons into SPs, obviating the need for the prism used in conventional SPR instruments, while...

This paper presents sufficient conditions for the design of strictly positive real (SPR), fixed-order dynamic compensators. The primary motivation for designing SPR compensators is for application to positive real (PR) plants. When an SPR compensator is connected to a PR plant in a negative feedback configuration, the closed loop is guaranteed stable for arbitrary plant variations as long as th...

We demonstrated enhanced surface plasmon resonance (SPR) detection by incorporating an indium tin oxide (ITO) layer on a thin gold film. Porous ITO layers were fabricated by e-beam evaporation and slanted deposition at room temperature and the ITO structure was optimized in terms of the surface roughness and the SPR curve characteristics. In sensing experiments, the results obtained by ethanol–...