Benzalkonium chloride (BAK) is a mixture of alkyl benzyl dimethyl ammonium chlorides, which used primarily as biocide, surfactant, preservative, and antimicrobial agent in the pharmaceutical industry, particular ophthalmologic nasal solutions. However, BAK may cause harmful consequences on eye structures anterior segment. Control identity content necessary by applying sensitive detection method...

Matrix metalloproteinases (MMPs) regulate composition of the extracellular matrix and play a critical role in cancer, fibrosis, and wound healing. This article describes a novel peptide-based electrochemical biosensor for detecting activity of cell-secreted protease MMP9. In this sensing strategy, a peptide specific to MMP9 was modified with a redox label (methylene blue (MB)) and immobilized o...

Vitamin B₉ or folic acid is an important food supplement with wide clinical applications. Due to its importance and its side effects in pregnant women, fast determination of this vitamin is very important. In this study we present a new fast and sensitive voltammetric sensor for the analysis of trace levels of vitamin B₉ using a carbon paste electrode (CPE) modified with 1,3-dipropylimidazolium...

A multiplexed, microfluidic platform to detect reactive metabolites is described, and its performance is illustrated for compounds metabolized by oxidative and bioconjugation enzymes in multi-enzyme pathways to mimic natural human drug metabolism. The device features four 8-electrode screen printed carbon arrays coated with thin films of DNA, a ruthenium-polyvinylpyridine (RuPVP) catalyst, and ...

Electrochemical behaviors of methocarbamol (MET) at the bare carbon paste electrode (CPE), acetylene black (AB) modified carbon paste electrode (AB/CPE), an ionic liquid 1-Benzyl-3Methylimidazole hexafluorophosphate ([BnMIM]PF6) modified carbon paste electrode ([BnMIM]PF6/ CPE) and AB-[BnMIM]PF6 modified carbon paste electrode (AB-[BnMIM]PF6/CPE) in PBS (pH = 6.8) were investigated by cyclic vo...

A facile and efficient molecularly imprinted polymer (MIP) recognition element of electrochemical sensor was fabricated by directly electro-polymerizing monomer o-phenylenediamine (oPD) in the presence of template quinoxaline-2-carboxylic acid (QCA), based on one-step controllable electrochemical modification of poly(pyrrole)-graphene oxide-binuclear phthalocyanine cobalt (II) sulphonate (PPY-G...

The screening and impurity profiling of drugs, like cocaine, is essential information that provides chemical and/or physical characterization to assist police agencies in understanding the trafficking identifying drug origin. This work proposes show development applications two different electronic tongues (e-tongues) on study cocaine seized samples. developed intelligent devices' primary objec...

Illicit drug consumption is posing critical concerns in our society causing health issues, crime-related activities and the disruption of border trade. The smuggling illicit drugs urges development new tools for rapid on-site identification cargos. Current methods used by law enforcement offices rely on presumptive color tests portable spectroscopic techniques. However, these sometimes exhibit ...

We report the first use of an electrochemical aptasensor for selective potassium recognition, based on a conformational change, affording an electric signal transduced electrochemically by square wave voltammetry or electrochemical impedance spectroscopy.