OBJECTIVE To assess the relative effectiveness of combining self-management and strength training for improving functional outcomes in patients with early knee osteoarthritis. METHODS We conducted a randomized intervention trial lasting 24 months at an academic medical center. Community-dwelling middle-aged adults (n = 273) ages 35-64 years with knee osteoarthritis, pain, and self-reported ph...

BACKGROUND Whether passive measures of isokinetic muscle strength deficits and knee laxity are related to the dynamic function of the anterior cruciate ligament-deficient knee remains unclear. HYPOTHESES Arthrometer measurements are not predictive of peak external knee flexion moment (net quadriceps muscle moment), isokinetic quadriceps muscle strength correlates with peak external knee flexi...

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Stair climbing is a functional activity that is essential to independent mobility in most community settings. The inability to use stairs to access multi-story facilities may create a social disadvantage for some older adults, not to mention an increased injury risk. Although statistics on falls and fall-related injuries among older adults have been well documented by multiple investigators, fe...

OBJECTIVES Stair climbing (SC) as daily activity is assessed with different SC-tests, but none directly measures ground reaction force over several steps. The Leonardo Mechanograph Stair A has five steps and four force sensors. This study aimed at investigating the reliability of the Stair A test for force, power and time to SC. METHODS 55 healthy participants (age: 48±14 years) were five tim...

Seven hundred and thirty-two parents reported when and how their infants learned to climb stairs. Children typically mastered stair ascent (mean age=10.97 months) several months after crawling onset and several weeks prior to descent (mean age=12.53 months). Most infants (94%) crawled upstairs the first time they ascended independently. Most infants (76%) turned around and backed at initial des...

BACKGROUND AND PURPOSE We sought to assess the specific influence of sex on rehabilitation results. METHODS A case-control study in 440 consecutive patients with sequelae of first ischemic stroke were enrolled in 2 subgroups (males and females) and matched for severity of stroke (evaluated by means of the Canadian Neurological Scale), age (within 1 year), and onset-admission interval (within ...

Background: No standards reflecting the quality of life (QOL) and activity of daily living (ADL) in postoperative clinical course have been validated in the area of vascular disease. The Walking Impairment Questionnaire (WIQ) is a disease-specific questionnaire that evaluates patients with intermittent claudication due to arteriosclerosis obliterans (ASO). The WIQ uses four subscales: pain seve...

Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) is a very rare inherited lysosomal storage disease. We evaluated the efficacy and safety of weekly infusions of recombinant human arylsulfatase B as enzyme replacement therapy for two patients in whom this condition was advanced. The primary outcome variables were the distance walked in a 6-minute walk test, forced vital capacity, and ejection ...