We describe the identification and characterization of a novel PcG gene in C. elegans, sor-1, which is involved in global repression of Hox genes. sor-1 encodes a novel protein with an RNA-binding activity. We provide evidence that SOR-1 and the previously identified RNA-binding protein SOP-2 may constitute an RNA-binding complex in Hox gene repression. SOR-1 and SOP-2 directly interact with ea...

Core ‘SOP 07: Data Flow, Monitoring, and Archiving’ was written under the assumption that a trial is sponsored by a pharmaceutical company that also takes the responsibility of monitoring according to Good Clinical Practice (GCP). The SOP 07a is a supplement to SOP 07 and describes the monitoring procedures in more detail. It is applicable if – The supplier of an investigational drug decides to...

The radiology installation is one of the supporting specialist medical services at hospital that uses x-rays for diagnosis. One efforts to protect workers from occupational health and safety in installations implement a radiation Personal Protective Equipment (PPE) management system. This type research descriptive qualitative with observation data collection techniques, interviews two informant...

This paper considers an optimization method of programmable logic arrays (PLAs), which have two-input EXOR gate at the outputs. The PLA realizes an EXOR of two sum-of-products expressions (EX-SOP) for multiple-valued input two-valued output functions. We present techniques to minimize EX-SOPs, which is an extension of Dubrova-Miller-Muzio’s AOXMIN algorithm. We conjecture that, when n is suffic...

*Correspondence: [email protected] Department of Applied Mathematics, Pukyong National University, Busan, 608-737, Korea Abstract A linear optimization problem over a symmetric cone, defined in a Euclidean Jordan algebra and called a self-scaled optimization problem (SOP), is considered. We formulate an algorithm for a large-update primal-dual interior-point method (IPM) for the SOP by using a p...

Quantum-dot Cellular Automata (QCA) is a nanotechnology which has potential applications in future computers. In this paper, a method for reducing the number of majority gates (a QCA logic primitive) is developed to facilitate the conversion of SOP expressions of three-variable Boolean functions into QCA majority logic. Thirteen standard functions are proposed to represent all three-variable Bo...

Recent studies have uncovered a key role of endocytosis during Notch signalling after the asymmetric division of the fly sensory organ precursor cells (SOP): directional signalling is mediated by differential endocytosis of the ligand Delta and the Notch effector Sanpodo in one of the SOP daughters, the pIIb. Here we show a novel mechanism of directional signalling based on the trafficking of D...

The pattern of the sensory bristles in the fruit fly Drosophila is remarkably reproducible. Each bristle arises from a sensory organ precursor (SOP) cell that is selected, through a lateral inhibition process, from a cluster of proneural cells. Although this process is well characterized, the mechanism ensuring its robustness remains obscure. Using probabilistic modeling, we defined the sources...

It is not rare that the performance of one metaheuristic algorithm can be improved by incorporating ideas taken from another. In this article we present how Simulated Annealing (SA) can be used to improve the efficiency of the Ant Colony System (ACS) and Enhanced ACS when solving the Sequential Ordering Problem (SOP). Moreover, we show how the very same ideas can be applied to improve the conve...