Central functions in the cell are often linked to complex dynamic behaviours, such as sustained oscillations and multistability, in a biochemical reaction network. Determination of the specific mechanisms underlying such behaviours is important, e.g. to determine sensitivity, robustness, and modelling requirements of given cell functions. In this work we adopt a systems approach to the analysis...

A laboratory experiment has been conducted in which a small basin was heatedfrom below. This basin was connected to a large reservoir that was filled with a layerof salt water at the bottom and fresh water above it, by tubes at the top, the middleand the bottom. It was shown that different flow regimes exist in this experiment. Forlow forcing temperatures, self-sustained osc...

Stimulus-induced perturbations from the steady state are a hallmark of signal transduction. In some signaling modules, the steady state is characterized by rapid synthesis and degradation of signaling proteins. Conspicuous among these are the p53 tumor suppressor, its negative regulator Mdm2, and the negative feedback regulator of NFκB, IκBα. We investigated the physiological importance of this...

In most cognitive neuroscience experiments there are many behavioral and experimental dynamics, and many indices of brain activity, that vary from trial to trial. For example, in studies of response conflict, conflict is usually treated as a binary variable (i.e., response conflict exists or does not in any given trial), whereas some evidence and intuition suggests that conflict may vary in int...

A droplet bouncing on the surface of a vertically vibrating liquid bath can walk horizontally, guided by waves it generates each impact. This results in self-propelled classical particle-wave entity. By using one-dimensional theoretical pilot-wave model with generalized wave form, we investigate dynamics this We employ different spatial forms to understand role played both oscillations and deca...

Neural oscillations occur within a wide frequency range with different brain regions exhibiting resonance-like characteristics at specific points in the spectrum. At the microscopic scale, single neurons possess intrinsic oscillatory properties, such that is not yet known whether cortical resonance is consequential to neural oscillations or an emergent property of the networks that interconnect...

Receptor-mediated oscillations in cytosolic Ca(2+) concentration ([Ca(2+)]i) could originate either directly from an autonomous Ca(2+) feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations driven by Ca(2+) feedback on IP3 metabolism. It is challenging to discriminate these alternatives, because IP3 fluctuations could drive Ca(2+...

Addition of Ca++ to rat liver mitochondria suspended in buffered 80 mM KC1 or NaCl causes activation of respiration, uptake of Ca++, and ejection of H+, followed by return of the respiratory rate to a resting steady state in which there are no further net movements of Ca++ and H+. However, when the KC1 concentration is only 20 mM, the Ca++-induced respiratory jump is followed by a period in whi...