A computer algorithm was developed and applied to measure brightness decay rates of myocardial contrast opacification observed with two-dimensional echocardiography (2DE). An agitated mixture of diatrizoate meglumine and saline (Renografin-saline) was injected into the left main coronary artery of 17 closed-chest dogs during the control state as well as after placement of an intracoronary plug ...

BACKGROUND AND PURPOSE Optimization of coronary risk evaluation in stroke patients has been encouraged. The relationship between symptomatic intracranial atherosclerosis and occult coronary artery disease (CAD) has not been evaluated sufficiently. We aimed to investigate the prevalence of silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis and to identify factor...

Background. Bilateral severe obstruction of the internal carotid artery is a hemodynamically critical state. We aimed to (1) analyze dynamic cerebral autoregulation (DCA) in affected patients, and (2) to correlate DCA data with different collateral flow patterns. Methods. DCA was assessed noninvasively by transfer function analysis (phase shift) of respiratory induced oscillations at 0.1 Hz of ...

Numerous CFD studies have been performed on the motivation to elucidate the role of hemodynamic forces in the development of atherosclerosis in the coronary arteries and the carotid bifurcation artery. In order to improve CFD predictions, and to consider CFD as a clinical diagnostic or treatment planning tool, there is a need to ensure its accuracy and reliability through a systematic approach ...

O’RIORDAN, JOHN B., JOHN T. FLAHERTY, SHUKRI F. KHURI, ROBERT K. BRAWLEY, BERTRAM PITT, AND VINCENT L. GOTT. Effects of atrial pacing on regional myocardial gas tensions with critical coronary stenosis. Am. J. Physiol. 232(l): H49-H53, 1977 or Am. J. Physiol.: Heart Circ. Physiol. l(1): H49-H53, 1977. -Changes in myocardial carbon dioxide (Pm& and oxygen tension (Pm& measured by mass spectromet...

BACKGROUND The effects of the endothelium-dependent vasodilator substance P (SP) on atherosclerotic human coronary arteries was studied. METHODS AND RESULTS [125I]-SP binding to luminal cells was shown to be preserved in the atherosclerotic epicardial coronary arteries of four patients. No binding to medial smooth muscle cells was demonstrated. Intracoronary infusions of SP were undertaken in...

In the current work, a three-dimensional geometry of a 75% stenosed blood vessel is analyzed. Large eddy simulation (LES) with the help of a dynamic subgrid scale Smagorinsky model is applied to model the turbulent pulsatile flow. The geometry, the transmural pressure and the properties of the blood and the elastic boundary were based on clinical measurement data. For the flexible wall model, a...

BACKGROUND The aim of this randomised pilot study was to investigate the haemodynamic effects measured by oxygen-15 positron emission tomography (PET) of interventional treatment consisting of either endarterectomy or endovascular treatment of stenosed cerebropetal arteries, or tapering of antihypertensive medication in comparison with standard medical treatment alone in patients with symptomat...