Somerville (2004b) developed FDR step-down procedures which were particularly appropriate for cases where the number of false hypotheses was small. The test statistics were assumed to have a multivariate-t distribution with common correlation. MCV’s (minimum critical values) were chosen so that 8 unique critical values resulted. Tables were given for numbers of hypotheses m, ranging from 50 to ...

Step Down Units (SDUs) were initially introduced in hospitals in order to provide an intermediate level of care for semi-critically ill patients who are not sick enough to require intensive care but not stable enough to be treated in the general medical/surgical ward. However, there is a lack of consensus within the medical community as to how these units should be used as well as the impact of...

David Cameron's plans for nursing would represent a backward step for the profession if they were implemented (news May 13, analysis May 20). Nursing is a career for dedicated individuals who are not afraid of responsibility or decision-making.

The buck or step-down DC-DC converter is the workhorse switching power supply topology. It utilizes two switches (two FETS or one FET and one diode) along with an output inductor and output capacitor. Whether you look at a large computer server, a personal desktop or a laptop computer, a cell phone or a GPS unit all will contain a buck converter in one form or another. This paper will discuss t...

Enalapril treatment (20 mg every 12 hours) of 24 patients with essential hypertension and left ventricular (LV) hypertrophy established normal blood pressures after 8 weeks, and after 5 years, it had reduced LV mass index by 39% (from 148+/-34 to 90+/-16 g/m(2)) and had normalized LV structure and function and QT dispersion. Stepwise reduction of the enalapril dosage from 40 to 30, 20, 10, and ...

The aim of this study was to determine whether the internal model regulating grip force (GF)/load force (LF) coordination during a brisk load increase is preserved when the lower extremities produce a perturbation during a single step-down task. We observed the coordination of the vertical ground reaction force (vGRF), GF and LF while holding a handheld object during a single step-down task. Th...

Because the inductive noise Ldi/dt is induced by the power change and can have disastrous impact on the timing and reliability of the system, high-performance CPU designs are more concerned with the step power reduction instead of the average power reduction. The step power is defined as the power difference between the previous and present clock cycles, and represents the Ldi/dt noise at the m...

The emergency of effective biological therapy in the treatment of Crohn's disease (CD) has led to a clinical debate about 'step-up versus top-down strategy'. Step-up refers to the classic therapeutic approach, namely progressive intensification of treatment as disease severity increases. Top-down refers to the early introduction, in all CD patients, of intensive therapies, including biological ...

In a Step-down procedure, apart from an hierarchy of the component hypotheses (leading to the steps), one also needs to settle on, their individual levels of significnace (constrained on the overall one). The Fisher method of combining independent tests is extended to the step-down procedure and its Bahadur-efficiency and (asymptotic) optimality results are considered.

Marden and Perlman (1988) have shown that the classical step-down procedure the Hotelling T 2 testing problem is inadmissible in most cases. Mudholkar and Subbaiah (1980) proposed a modified step-down procedure wherein the p-values associated with sten-wise F tests are combined according to Fisher's combination method. In the present paper it is shown that the modified step-down procedure is in...