Various substituted Dispiro [pyrrolo-piperazino-oxindole] have been synthesized by utilizing a simple and efficient two-step synthetic protocol Grubbs metathesis in dichloromethane at 40°C. The structures relative stereochemistry of the cycloadduct were confirmed single-crystal X-ray diffraction, 1H 13C NMR spectroscopy, mass spectrometry.
 
 Keywords: Hexahydro-diazecane-dione, Metat...

In this research, Quantum-mechanical calculations were performed at the HF method with the 6-31+G*basis set and at the B3LYP method with the 6-31+G* basis set in the gas phase and five solvents such as water, DMSO, methanol, ethanol and dichloromethane at six temperatures. According to these theoretical results of IR, we extracted thermo chemical parameters such as enthalpy (∆H Kcal/mol), Gibbs...

Embodied learning tools (ELTs), such as building and manipulating models, bolster students’ of spatially demanding science content, stereochemistry. However, studies comparing the effectiveness virtual to physical ELTs on student are limited. This study compares online instruction using a ELT, organic chemistry students' stereochemistry understanding. Furthermore, it identifies which tool promo...

The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5'' position.