BACKGROUND AND PURPOSE To determine appropriate risk-stratification factors for prostate cancer patients undergoing stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS Between 2006 and 2010, 515 patients with organ-confined prostate cancer were treated with a regimen of five-fraction SBRT to dose of 35-36.25 Gy. By NCCN criteria, 324 patients were low risk, 153 were intermediate risk...

Almost 20 years ago, Emami et al. presented a comprehensive set of dose tolerance limits for normal tissue organs to therapeutic radiation, which has proven essential to the field of radiation oncology. The paradigm of stereotactic body radiotherapy (SBRT) has dramatically different dosing schemes but, to date, there has still been no comprehensive set of SBRT normal organ dose tolerance limits...

A 58-year-old woman presented with severe fatigue, headache, diplopia, and a transient paresis of the left leg. Magnetic resonance imaging revealed a solitary rightsided lesion of the cerebral peduncle, without further signs of systemic disease or primary tumor. A stereotactic biopsy of the lesion was performed. Histopathological examination showed adenocarcinoma, presumably of lung origin. The...

Primary synovial sarcoma of kidney is an uncommon neoplasm, metastasizing most commonly to lung. Surgery and/or palliative chemotherapy for pulmonary metastases is commonly used to improve tumor control and survival. Stereotactic body radiotherapy (SBRT) is a relatively new approach to treat pulmonary metastasis, encouraged by the results of cranial and spinal stereotactic radiosurgery. The loc...

3D Isodoselines innovation with Interior Optimization (IO) for prostate tumor BED model hyperfractionated Treatment Planning (TPO) application is further demonstrated. The implemented data was got additional-dual constrained evolutionary algorithm BED-LQ (Biological Effective Dose) in this cancer type. Results TPO IO-Graphical show a number of surfactal IO proven accuracy-feasibility the novelt...

Historically, Radiation Therapy (RT) has played a minor role in the treatment of hepatocellular carcinoma, especially because of toxicity related to conventional techniques. However, high radiation doses can now be given safely by means of 3D-conformal techniques and other more specialized techniques. 3D-conformal RT, in which both target definition and treatment planning are based on three-dim...

Patients with metastatic solid tumors are usually treated with palliative intent. Systemic therapy and palliative radiation are often used, with the goals of prolonging survival or maintaining quality of life, but not of cure. In contrast to this paradigm, the theory of oligometastasis suggests that some patients who have a small number of metastases may be amenable to cure if all lesions can b...

Stereotactic ablative radiotherapy (SABR), which is also referred to as stereotactic body radiotherapy (SBRT), is defined as “the precise irradiation of an image defined extra-cranial lesion associated with the use of high radiation dose in a small number of fractions”. SABR is a relatively recent advance in the treatment of small peripheral non-small cell lung tumours. The concept of SABR was ...

BACKGROUND Stereotactic radiosurgery is widely applied to deliver additional dose to head and neck tumors. However, its safety and efficacy remains equivocal. METHODS One hundred eighty-four patients with primary head and neck cancers treated between January 1990 and August 2012 with Gamma Knife stereotactic radiosurgery were retrospectively reviewed. RESULTS Two hundred fifteen sites were ...

The best treatment approach for solitary brain metastasis is not well defined and there is no consensus on this issue. It is still being debated whether patients with isolated brain metastasis should undergo surgical resection or stereotactic radiosurgery, and which patients should receive adjuvant whole brain radiotherapy. The median survival in patients with single or multiple metastatic lesi...